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Association of Adam33 T1 Polymorphism With Subgroups of Pediatric Asthma Patients in Iran



Ghaemi MR1 ; Hemmati S2, 3 ; Rezaei A2 ; Sadr M4 ; Mohebbi B2 ; Ghaffaripour H5 ; Rezaei N2, 6, 7 ; Mahdaviani SA5
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  2. 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Molecular Medicine Interest Group (MMIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis And Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: Acta Medica Iranica Published:2019

Abstract

There is strong evidence on the interaction of several genetic variations and environmental conditions in the etiology of asthma. Association of a disintegrin and metalloproteinase 33 (ADAM33) with asthma risk is not clear and shows diversity between nations and ethnicities. Several single nucleotide polymorphisms (SNP) of the ADAM33 gene are introduced and studied according to the disease onset and characteristics. The aim of our study is to determine the association of ADAM33 rs2280091 polymorphism and pediatric asthma in the Iranian population. A total of 63 asthma patients (aged 6-18) and 86 healthy controls were enrolled in our study. Asthma type, classification, and severity were defined. SNPs of the ADAM33 gene at rs2280091 (T1) were analyzed. Pulmonary function tests, total blood eosinophil count, and IgE count were also assessed. T1 genotype and allele frequencies were not associated with asthma risk in Iranian pediatric asthma. Atopic asthma subgroup and patients with normal eosinophil count showed association with ADAM33 rs2280091. Moreover, asthma patients with AG genotype showed lower pulmonary functions. © 2019 Tehran University of Medical Sciences. All rights reserved.
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