Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma

Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma Publisher Pubmed

Sajayasbaghi M¹ ; Sadeghishabestrai M² ; Monfaredan A³ ; Seyfizadeh N^{4, 5} ; Razavi A¹ ; Kazemi T²

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1. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3. Research Division of Tabriz International Hospital, Tabriz, Iran
4. Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany
5. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Personalized Medicine Published:2020

Abstract

Aim: Siglec-8 is exclusively expressed on mast cells, eosinophils and basophils. Possible association of six siglec-8 single nucleotide polymorphisms (SNPs) with susceptibility to allergic asthma in the Azeri population of Iran was investigated in this study. Materials & methods: A total of 194 patients and 190 normal subjects were enrolled. PCR single strand conformation polymorphism (PCR-SSCP) was used to determine the genotypes of the studied SNPs. Results: The rs36498 showed significant association with allergic asthma (odds ratio [OR]: 0.65; p = 0.022) and the T allele was found as a protective allele (OR: 0.61; p = 0.008). Also, eosinophil count in the CC genotype was significantly higher than that in the other genotypes (p = 0.026). Conclusion: The rs36498 is thought to influence the expression level of siglec-8. Siglec-8 could be a potential therapeutic target for allergic asthma. © 2020 Future Medicine Ltd.

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Style	Citing Format
MLA	Sajayasbaghi M, et al.. "Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma." Personalized Medicine, vol. 17, no. 3, 2020, pp. 195-201.
APA	Sajayasbaghi M, Sadeghishabestrai M, Monfaredan A, Seyfizadeh N, Razavi A, Kazemi T (2020). Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma. Personalized Medicine, 17(3), 195-201.
Chicago	Sajayasbaghi M, Sadeghishabestrai M, Monfaredan A, Seyfizadeh N, Razavi A, Kazemi T. "Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma." Personalized Medicine 17, no. 3 (2020): 195-201.
Harvard	Sajayasbaghi M et al. (2020) 'Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma', Personalized Medicine, 17(3), pp. 195-201.
Vancouver	Sajayasbaghi M, Sadeghishabestrai M, Monfaredan A, Seyfizadeh N, Razavi A, Kazemi T. Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma. Personalized Medicine. 2020;17(3):195-201.
BibTex	@article{ author = {Sajayasbaghi M and Sadeghishabestrai M and Monfaredan A and Seyfizadeh N and Razavi A and Kazemi T}, title = {Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma}, journal = {Personalized Medicine}, volume = {17}, number = {3}, pages = {195-201}, year = {2020} }
RIS	TY - JOUR AU - Sajayasbaghi M AU - Sadeghishabestrai M AU - Monfaredan A AU - Seyfizadeh N AU - Razavi A AU - Kazemi T TI - Promoter Region Single Nucleotide Polymorphism of Siglec-8 Gene Associates With Susceptibility to Allergic Asthma JO - Personalized Medicine VL - 17 IS - 3 SP - 195 EP - 201 PY - 2020 ER -

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