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A Review of Driver Genetic Alterations in Thyroid Cancers Publisher



Khatami F1 ; Tavangar SM2
Authors
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Authors Affiliations
  1. 1. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Dept. of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pathology Published:2018


Abstract

Thyroid cancer is a frequent endocrine related malignancy with continuous increasing incidence. There has been moving development in understanding its molecular pathogenesis recently mainly through the explanation of the original role of several key signaling pathways and related molecular distributors. Central to these mechanisms are the genetic and epigenetic alterations in these pathways, such as mutation and DNA rearrangements. That does not mean, however, that all the somatic abnormalities here in a cancer genome have been involved in development of the cancer and just driver mutations are concerned in tumor initiation. By way of illustrations, MAPK pathway which is motivated by BRAFV600Eand RAS and RET/ PTC rearrangements are suggesting driver genetic alterations in follicular derived thyroid cancers which are considered in this review. © 2018, IRANIAN JOURNAL OF PATHOLOGY.
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