Beyond the Division of Multiple Sclerosis Into Different Subgroups: The Concept of Connectomopathy Publisher



Moghadasi AN¹ ; Rezaeimanesh N¹ Show Affiliations
Source: Caspian Journal of Internal Medicine Published:2024

Abstract

Multiple Sclerosis (MS) pathophysiologically is a dynamic and progressive disease that involves all parts of central nervous system. This widespread involvement of the CNS has paved the way for proposing a new theory in MS in which MS is considered as a connectomopathy. Connectomopathy is a new concept describing the diseases in which not only the brain connectome is completely and extensively damaged, but the defective connectome itself can also become a breeding ground for the disease’s progression. Connectomopathy provides a dynamic picture of MS. Since each person’s connectome is unique to him/herself, so MS patients’ connectomopathy varies from one to another. This variety not only challenges the classification of MS into different phenotypes, but also emphasizes the need for providing a personalized approach for the treatment of these patients. © The Author(s)