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Prolonged Drug Release Using Pcl–Tmz Nanofibers Induce the Apoptotic Behavior of U87 Glioma Cells Publisher



Tavakoli R1 ; Vakilian S1, 2 ; Jamshidiadegani F1, 2 ; Sharif S3 ; Ardeshirylajimi A4 ; Soleimani M5
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2018


Abstract

In situ prolonged delivery of drugs at the site of tumor can be satisfactorily accelerated patient recovery. We compared the effect of temozolomide while incorporated by polycaprolactone nanofibers on the apoptotic behavior of U87 glioma cells. After biocompatibility evaluation of nanofibers by scanning electron microscope and 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide analysis, the apoptosis of U87 cells was evaluated using p53, Bcl2 and Bax genes expression. It was found that nanofiber-temozolomide group showed a greater ability to induce apoptosis as well as have a significantly diminished initial burst release of drug compared with other groups and have promising potential in treating cancer. GRAPHICAL ABSTRACT. © 2017 Taylor & Francis.
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