Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies

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Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies Publisher

M Toolabi MAHSA ; A Basiri ALIREZA ; Fd Yaghouti Farhad DOROSTKAR ; M Safdarian MEHDI ; A Ayati ADILEH ; A Mojaddami AYYUB

Source: Results in Chemistry Published:2025

Abstract

This study presents the synthesis of a series of coumarin derivatives via efficient Ugi synthesis reactions, aimed at exploring their anti-proliferative properties. Out of the twelve synthesized derivatives, most exhibited significant anti-proliferative activity with minimal cytotoxic effects on normal MCF12A cells. Notably, compound 5i showed exceptional activity, achieving IC50 values of 17.69, 19.87, and 30.39 μM against HeLa, MCF-7, and A549 cell lines, respectively, comparable to Doxorubicin. Apoptosis assays revealed a pronounced dose-dependent effect, with apoptosis rates increasing to 22.75 % at 10 μM and 83.50 % at 40 μM. Additionally, molecular docking studies confirmed the compound's strong inhibitory potential against the anti-apoptotic Bcl-2 protein. These results highlight the promising role of compound 5i as an anticancer agent, warranting further exploration in therapeutic applications. © 2025 Elsevier B.V., All rights reserved.

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Style	Citing Format
MLA	M Toolabi MAHSA, et al.. "Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies." Results in Chemistry, vol. 16, no. , 2025, pp. -.
APA	M Toolabi MAHSA, A Basiri ALIREZA, Fd Yaghouti Farhad DOROSTKAR, M Safdarian MEHDI, A Ayati ADILEH, A Mojaddami AYYUB (2025). Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies. Results in Chemistry, 16(), -.
Chicago	M Toolabi MAHSA, A Basiri ALIREZA, Fd Yaghouti Farhad DOROSTKAR, M Safdarian MEHDI, A Ayati ADILEH, A Mojaddami AYYUB. "Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies." Results in Chemistry 16, no. (2025): -.
Harvard	M Toolabi MAHSA et al. (2025) 'Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies', Results in Chemistry, 16(), pp. -.
Vancouver	M Toolabi MAHSA, A Basiri ALIREZA, Fd Yaghouti Farhad DOROSTKAR, M Safdarian MEHDI, A Ayati ADILEH, A Mojaddami AYYUB. Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies. Results in Chemistry. 2025;16():-.
BibTex	@article{ author = {M Toolabi MAHSA and A Basiri ALIREZA and Fd Yaghouti Farhad DOROSTKAR and M Safdarian MEHDI and A Ayati ADILEH and A Mojaddami AYYUB}, title = {Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies}, journal = {Results in Chemistry}, volume = {16}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - M Toolabi MAHSA AU - A Basiri ALIREZA AU - Fd Yaghouti Farhad DOROSTKAR AU - M Safdarian MEHDI AU - A Ayati ADILEH AU - A Mojaddami AYYUB TI - Coumarin Derivatives As Potential Anticancer Agents: Synthesis, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies JO - Results in Chemistry VL - 16 IS - SP - EP - PY - 2025 ER -

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