Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major

Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major Publisher

Sadatebrahimi SE¹ ; Mirmohammadi M¹ ; Tabatabaei ZM² ; Arani MA³ ; Jafariashtiani S¹ ; Hashemian M¹ ; Foroumadi P¹ ; Yahyameymandi A¹ ; Moghimi S³ ; Moshafi MH⁴ ; Norouzi P¹ ; Ardestani SK² ; Foroumadi A^{1, 3}

Source: Iranian Journal of Pharmaceutical Research Published:2019

Abstract

In this study, a series of novel compounds based on 5-(5-nitrothiophene2--yl)-1,3,4-thiadiazole possessing (het) aryl thio pendant at C-2 position of thiadiazole ring is developed and evaluated as antileishmanial agents using MTT colorimetric assay. 10 New compounds containing aryl and heteroaryl derivatives, started from thiophene-2-carbaldehyde in five steps, were synthesized in good to excellent yields and characterized by1H-NMR,13C-NMR, and IR spectroscopy. Through the compounds 6a-j, methylimidazole containing derivative 6e was recognized as the most active compound against L. major promastigotes exhibiting IC50 values of 11.2µg/mL and 7.1µg/mL after 24 and 48 h, respectively. This compound is > 4 fold more effective than Glucantime as a standard drug (IC50 = 50 µg/mL after 24 h and 25 µg/mL after 48 h). © 2019, Iranian Journal of Pharmaceutical Research. All rights reserved.

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Alireza Foroumadi (3)

Nasim Vousooghi (1)

Style	Citing Format
MLA	Sadatebrahimi SE, et al.. "Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major." Iranian Journal of Pharmaceutical Research, vol. 18, no. 4, 2019, pp. 1816-1822.
APA	Sadatebrahimi SE, Mirmohammadi M, Tabatabaei ZM, Arani MA, Jafariashtiani S, Hashemian M, Foroumadi P, Yahyameymandi A, Moghimi S, Moshafi MH, Norouzi P, Ardestani SK, Foroumadi A (2019). Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major. Iranian Journal of Pharmaceutical Research, 18(4), 1816-1822.
Chicago	Sadatebrahimi SE, Mirmohammadi M, Tabatabaei ZM, Arani MA, Jafariashtiani S, Hashemian M, Foroumadi P, et al.. "Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major." Iranian Journal of Pharmaceutical Research 18, no. 4 (2019): 1816-1822.
Harvard	Sadatebrahimi SE et al. (2019) 'Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major', Iranian Journal of Pharmaceutical Research, 18(4), pp. 1816-1822.
Vancouver	Sadatebrahimi SE, Mirmohammadi M, Tabatabaei ZM, Arani MA, Jafariashtiani S, Hashemian M, et al.. Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major. Iranian Journal of Pharmaceutical Research. 2019;18(4):1816-1822.
BibTex	@article{ author = {Sadatebrahimi SE and Mirmohammadi M and Tabatabaei ZM and Arani MA and Jafariashtiani S and Hashemian M and Foroumadi P and Yahyameymandi A and Moghimi S and Moshafi MH and Norouzi P and Ardestani SK and Foroumadi A}, title = {Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major}, journal = {Iranian Journal of Pharmaceutical Research}, volume = {18}, number = {4}, pages = {1816-1822}, year = {2019} }
RIS	TY - JOUR AU - Sadatebrahimi SE AU - Mirmohammadi M AU - Tabatabaei ZM AU - Arani MA AU - Jafariashtiani S AU - Hashemian M AU - Foroumadi P AU - Yahyameymandi A AU - Moghimi S AU - Moshafi MH AU - Norouzi P AU - Ardestani SK AU - Foroumadi A TI - Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major JO - Iranian Journal of Pharmaceutical Research VL - 18 IS - 4 SP - 1816 EP - 1822 PY - 2019 ER -

Style

Citing Format

MLA

Sadatebrahimi SE, et al.. "Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major." Iranian Journal of Pharmaceutical Research, vol. 18, no. 4, 2019, pp. 1816-1822.

APA

Sadatebrahimi SE, Mirmohammadi M, Tabatabaei ZM, Arani MA, Jafariashtiani S, Hashemian M, Foroumadi P, Yahyameymandi A, Moghimi S, Moshafi MH, Norouzi P, Ardestani SK, Foroumadi A (2019). Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major. Iranian Journal of Pharmaceutical Research, 18(4), 1816-1822.

Chicago

Sadatebrahimi SE, Mirmohammadi M, Tabatabaei ZM, Arani MA, Jafariashtiani S, Hashemian M, Foroumadi P, et al.. "Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major." Iranian Journal of Pharmaceutical Research 18, no. 4 (2019): 1816-1822.

Harvard

Sadatebrahimi SE et al. (2019) 'Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major', Iranian Journal of Pharmaceutical Research, 18(4), pp. 1816-1822.

Vancouver

Sadatebrahimi SE, Mirmohammadi M, Tabatabaei ZM, Arani MA, Jafariashtiani S, Hashemian M, et al.. Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major. Iranian Journal of Pharmaceutical Research. 2019;18(4):1816-1822.

BibTex

@article{ author = {Sadatebrahimi SE and Mirmohammadi M and Tabatabaei ZM and Arani MA and Jafariashtiani S and Hashemian M and Foroumadi P and Yahyameymandi A and Moghimi S and Moshafi MH and Norouzi P and Ardestani SK and Foroumadi A}, title = {Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major}, journal = {Iranian Journal of Pharmaceutical Research}, volume = {18}, number = {4}, pages = {1816-1822}, year = {2019} }

RIS

TY - JOUR
AU - Sadatebrahimi SE
AU - Mirmohammadi M
AU - Tabatabaei ZM
AU - Arani MA
AU - Jafariashtiani S
AU - Hashemian M
AU - Foroumadi P
AU - Yahyameymandi A
AU - Moghimi S
AU - Moshafi MH
AU - Norouzi P
AU - Ardestani SK
AU - Foroumadi A
TI - Novel 5-(Nitrothiophene-2-Yl)-1,3,4-Thiadiazole Derivatives: Synthesis and Antileishmanial Activity Against Promastigote Stage of Leishmania Major
JO - Iranian Journal of Pharmaceutical Research
VL - 18
IS - 4
SP - 1816
EP - 1822
PY - 2019
ER -

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Abstract