Tim-3 Genetic Variants and Risk of Behcet Disease in the Iranian Population Publisher Pubmed



Ataei M¹ ; Behfarjam F¹ ; Jadali Z² Show Affiliations
Source: Anais Brasileiros de Dermatologia Published:2019

Abstract

Background: Behcet disease is a prototypical systemic autoimmune disease, caused by a complex interplay between environmental and genetic factors. The transmembrane immunoglobulin and mucin domain-3 (TIM-3) is a distinct member of the TIM family that is preferentially expressed on Th1 cells and plays a role in Th1-mediated autoimmune or inflammatory diseases, such as Behcet disease. Objective: The aim of this study was to test the potential association between TIM-3 gene polymorphisms and Behcet disease. Methods: Two single-nucleotide polymorphisms of TIM-3 (rs9313439 and rs10515746) were genotyped in 212 patients with Behcet disease and 200 healthy controls. Typing of the polymorphisms was performed using multiplex PCR amplification. Results: There were no significant differences in allele and genotype frequencies between the Behcet disease patients and controls who were successfully genotyped. Similar results were also found after stratification by gender, age, or clinical features. Study limitations: Lack of studies on various racial or ethnic groups and small sample size. Conclusion: This study failed to demonstrate any association between the tested TIM-3 polymorphisms and Behcet disease. © 2019 by Anais Brasileiros de Dermatologia.