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Association of Kir Genes and Their Hla Ligands Diversity With Colorectal Cancer in Lur Population of Iran Publisher



Shayanrad B1, 2 ; Ghanadi K3 ; Varzi AM2 ; Birjandi M4 ; Ahmadi SAY5, 6 ; Shahsavar F2
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Division of Gastroenterology, Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  4. 4. Department of Epidemiology and Biostatistics, Lorestan University of Medical Sciences, Khorramabad, Iran
  5. 5. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Scientific Society of Evidence-Based Knowledge, Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

Source: Meta Gene Published:2019


Abstract

Objectives: This study was aimed to evaluate the disease association of each killer-cell immunoglobulin-like receptor (KIR) genes and their known human leukocyte antigen (HLA) ligands (HLA-C and -Bw4) as well as KIR haplotypes and KIR-HLA interactions in Lur population of west of Iran. Methods: In this case-control study, 50 cases with colorectal cancer and 100 healthy controls were taken. The genomic DNA was extracted and polymerase chain reaction with sequence specific primers (PCR-SSP) was used to genotyping the samples. Statistical analysis was done using 2 by 2 tables. In order to compare the results with other previous studies, funnel plot and cluster analysis were used. Results: Among the single gene analyses, only the association of KIR2DS5 was statistically significant (Pearson chi-square P =.0206; Yate's corrected chi-square P =.0323; OR = 2.25 [1.12–4.49 95% CI]). No significant association was observed for neither KIR nor HLA genotypes. Among the KIR-HLA interactions, no significant association was observed as well. Conclusion: The results of this paper supported the results of previous studies as well as the rationale existing behind the tumor biology. The ligand of KIR2DS5 should be discovered and evaluated in future. © 2019 Elsevier B.V.
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