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Exploring Atm and Methylation in Cancer: Emphasizing on Brain Tumors Publisher



Mehdipour P1 ; Karami F1
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Poursina Street, Keshavarz Boulevard, P.O. Box: 14176-13151, Tehran, Iran

Source: Epigenetics Territory and Cancer Published:2015


Abstract

Ataxia-telangiectasia mutated (ATM) molecule governs one of the major cellular DNA repair pathway and is found to be crucial to inhibit cancer progression. Herein, after introducing the basic description about the ATM gene, its protein structure and functions, then we will discuss about the role of ATM gene aberrations in various types of cancers. It will be explained that some overlaps between Ataxia Telangiectasia (AT) patient and some other metabolic disorders relying on the importance of ATM gene mutations in the pathogenesis of AT disease. Finally, the spectrum of ATM promoter methyltion in different types of cancers will be provided. © Springer Science+Business Media Dordrecht 2015.
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