Potential Therapeutic Effects of Melatonin Mediate Via Mirnas in Cancer Publisher Pubmed



Pourmohammad P¹ ; Maroufi NF^{2, 3} ; Rashidi M⁴ ; Vahedian V^{5, 6} ; Pouremamali F⁷ ; Faridvand Y² ; Ghaffarinovin M⁸ ; Isazadeh A⁹ ; Hajazimian S⁹ ; Nejabati HR³ ; Nouri M³ Show Affiliations
Source: Biochemical Genetics Published:2022

Abstract

miRNAs are evolutionarily conserved non-coding ribonucleic acids with a length of between 19 and 25 nucleotides. Because of their ability to regulate gene expression, miRNAs have an important function in the controlling of various biological processes, such as cell cycle, differentiation, proliferation, and apoptosis. Owing to the long-standing regulative potential of miRNAs in tumor-suppressive pathways, scholars have recently paid closer attention to the expression profile of miRNAs in various types of cancer. Melatonin, an indolic compound secreted from pineal gland and some peripheral tissues, has been considered as an effective anti-tumor hormone in a wide spectrum of cancers. Furthermore, it induces apoptosis, inhibits tumor metastasis and invasion, and also angiogenesis. A growing body of evidence indicates the effects of melatonin on miRNAs expression in broad spectrum of diseases, including cancer. Due to the long-term effects of the regulation of miRNAs expression, melatonin could be a promising therapeutic factor in the treatment of cancers via the regulation of miRNAs. Therefore, in this review, we will discuss the effects of melatonin on miRNAs expression in various types of cancers. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.