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Angioregulatory Role of Mirnas and Exosomal Mirnas in Glioblastoma Pathogenesis Publisher Pubmed



Bouzari B1 ; Mohammadi S2 ; Bokov DO3, 4 ; Krasnyuk II4 ; Hosseinifard SR5 ; Hajibaba M6 ; Mirzaei R7, 8 ; Karampoor S6
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. ENT and Head and Neck Research Center and Department, Firoozgar General Hospital, The Five Senses Health Institute, Iran
  3. 3. Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, Russian Federation
  4. 4. Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, Russian Federation
  5. 5. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  8. 8. Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran

Source: Biomedicine and Pharmacotherapy Published:2022


Abstract

Glioblastoma (GB) is a highly aggressive cancer of the central nervous system, occurring in the brain or spinal cord. Many factors such as angiogenesis are associated with GB development. Angiogenesis is a procedure by which the pre-existing blood vessels create new vessels that play an essential role in health and disease, including tumors. Also, angiogenesis is one of the significant factors thought to be responsible for treatment resistance in many tumors, including GB. Hence, an improved understanding of the molecular processes underlying GB angiogenesis will pave the way for developing potential new treatments. Recently, it has been found that microRNAs (miRNAs) and exosomal miRNAs have a crucial role in inducing or inhibiting the angiogenesis process in GB development. A better knowledge of the miRNA's regulation pathway in the angiogenesis process in cancer offers unique mechanistic insight into the mechanism of tumor-associated neovascularization. Because of advancements in miRNA characterization and delivery methods, miRNAs can also be employed in clinical settings as potential biomarkers for anti-angiogenic treatment response as well as therapies targeting tumor angiogenesis. The recent finding and insights about miRNAs' angioregulatory role and exosomal miRNAs in GB are provided throughout the review. Also, we discuss the new concept of miRNAs-based therapies for GB in the future. © 2022 The Authors
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