Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag

Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag Publisher Pubmed

Esmaeili J¹ ; Barati A¹ ; Salehi E¹ ; Ai J²

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1. Department of Chemical Engineering, Faculty of Engineering, Arak University, Arak, 38156-88349, Iran
2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, 38156-88349, Iran

Source: Molecular Pharmaceutics Published:2023

Abstract

The clinical success of a drug delivery system turns back to performing experiments with more reliable data. The dialysis bag has been one of the most employed technologies to monitor drug release from nanocarriers, membranes, and scaffolds. Unfortunately, this technology has several challenges regarding the accuracy of the obtained results. In this study, the development of a new system by integrating a microfluidic device and dialysis bag named “MF-dialysis” was carried out to evaluate the accuracy of the reported data. The release study was performed focusing on two drug delivery systems: (i) nanocarrier: Artemisia Absinthium extract-loaded soy protein isolate nanoparticle and (ii) sodium alginate film loaded with the nanocarrier. The obtained nanocarrier was analyzed by SEM, DLS, and zeta potential. The final experimental data were modeled using SigmaPlot software. Based on the results, two distinct but fitted models for the dialysis bag (power model, R2 = 0.99) and MF-dialysis (exponential model, R2 = 0.95) were obtained. MF-dialysis approved that after a while, NPs and films showed more drug release compared to the dialysis bag. To sum up, the MF-dialysis system can be a good candidate for a quick and more reliable study of drug delivery systems. © 2023 American Chemical Society.

2. Fabrication and Evaluation of a Soy Protein Isolate/Collagen/Sodium Alginate Multifunctional Bilayered Wound Dressing: Release of Cinnamaldehyde, Artemisia Absinthium, and Oxygen, ACS Applied Bio Materials (2024)

Style	Citing Format
MLA	Esmaeili J, et al.. "Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag." Molecular Pharmaceutics, vol. 20, no. 2, 2023, pp. 1129-1137.
APA	Esmaeili J, Barati A, Salehi E, Ai J (2023). Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag. Molecular Pharmaceutics, 20(2), 1129-1137.
Chicago	Esmaeili J, Barati A, Salehi E, Ai J. "Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag." Molecular Pharmaceutics 20, no. 2 (2023): 1129-1137.
Harvard	Esmaeili J et al. (2023) 'Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag', Molecular Pharmaceutics, 20(2), pp. 1129-1137.
Vancouver	Esmaeili J, Barati A, Salehi E, Ai J. Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag. Molecular Pharmaceutics. 2023;20(2):1129-1137.
BibTex	@article{ author = {Esmaeili J and Barati A and Salehi E and Ai J}, title = {Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag}, journal = {Molecular Pharmaceutics}, volume = {20}, number = {2}, pages = {1129-1137}, year = {2023} }
RIS	TY - JOUR AU - Esmaeili J AU - Barati A AU - Salehi E AU - Ai J TI - Reliable Kinetics for Drug Delivery With a Microfluidic Device Integrated With the Dialysis Bag JO - Molecular Pharmaceutics VL - 20 IS - 2 SP - 1129 EP - 1137 PY - 2023 ER -

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