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Plant Protein-Based Hydrophobic Fine and Ultrafine Carrier Particles in Drug Delivery Systems Publisher Pubmed



Malekzad H1 ; Mirshekari H2 ; Sahandi Zangabad P3, 4, 5 ; Moosavi Basri SM6, 7 ; Baniasadi F4 ; Sharifi Aghdam M8 ; Karimi M9, 10, 11 ; Hamblin MR12, 13, 14
Authors
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Authors Affiliations
  1. 1. Advanced Nanobiotechnology and Nanomedicine Research Group (ANNRG), Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Biotechnology, University of Kerala, Trivandrum, India
  3. 3. Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Science (TUOMS), Tabriz, Iran
  4. 4. Department of Material Science and Engineering, Sharif University of technology, Tehran, Iran
  5. 5. Universal Scientific Education and Research Network (USERN), Tehran, Iran
  6. 6. Bioenvironmental Research Center, Sharif University of Technology, Tehran, Iran
  7. 7. Civil & Environmental Engineering Department, Shahid Beheshti University, Tehran, Iran
  8. 8. School of Advanced Technologies in Medicine, University of Tehran, Tehran, Iran
  9. 9. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran
  11. 11. Applied Biotechnology Research Center, School of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  12. 12. Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United States
  13. 13. Department of Dermatology, Harvard Medical School, Boston, MA, United States
  14. 14. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

Source: Critical Reviews in Biotechnology Published:2018


Abstract

For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes. Zein is a water-insoluble protein from maize; Gliadin is a 70% alcohol-soluble protein from wheat and corn; legumin is a casein-like protein from leguminous seeds such as peas; lectins are glycoproteins naturally occurring in many plants that recognize specific carbohydrate residues. NPs formed from these proteins show good biocompatibility, possess the ability to enhance solubility, and provide sustained release of drugs and reduce their toxicity and side effects. The effects of preparation methods on the size and loading capacity of these NPs are also described in this review. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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