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Targeting Mirna by Natural Products: A Novel Therapeutic Approach for Nonalcoholic Fatty Liver Publisher



Zobeiri M1 ; Parvizi F2 ; Kalhori MR3 ; Majnooni MB2 ; Farzaei MH2 ; Abdollahi M4
Authors
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Authors Affiliations
  1. 1. Internal Medicine Department, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
  2. 2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
  3. 3. Regenerative Medicine Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran
  4. 4. Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran

Source: Evidence-based Complementary and Alternative Medicine Published:2021


Abstract

The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) as multifactorial chronic liver disease and the lack of a specific treatment have begun a new era in its treatment using gene expression changes and microRNAs. This study aimed to investigate the potential therapeutic effects of natural compounds in NAFLD by regulating miRNA expression. MicroRNAs play essential roles in regulating the cell's biological processes, such as apoptosis, migration, lipid metabolism, insulin resistance, and adipocyte differentiation, by controlling the posttranscriptional gene expression level. The impact of current NAFLD pharmacological management, including drug and biological therapies, is uncertain. In this context, various dietary fruits or medicinal herbal sources have received worldwide attention versus NAFLD development. Natural ingredients such as berberine, lychee pulp, grape seed, and rosemary possess protective and therapeutic effects against NAFLD by modifying the gene's expression and noncoding RNAs, especially miRNAs. © 2021 Mehdi Zobeiri et al.
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