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The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia Publisher Pubmed



Yousefi M1, 2 ; Movassaghpour AA2 ; Shamsasenjan K2 ; Ghalamfarsa G3 ; Sadreddini S1 ; Jadidiniaragh F4 ; Hojjatfarsangi M5
Authors
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Authors Affiliations
  1. 1. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
  4. 4. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden

Source: Future Oncology Published:2015


Abstract

While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many immunopathologic conditions such as autoimmune and cancer diseases. B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the western world and is characterized with monoclonal expansion of B lymphocytes. There is evidence which implies that the progression of CLL is associated with expansion of Treg and downregulation of Th17 cells. In this review, we will discuss about immunobiology of Treg and Th17 cells and their role in immunopathogenesis of CLL as well as their reciprocal changes during disease progression. © 2015 Future Medicine Ltd.
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