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Determination of Diffusion Coefficient for Released Nanoparticles From Developed Gelatin/Chitosan Bilayered Buccal Films Publisher Pubmed



Mahdizadeh Barzoki Z1 ; Emamdjomeh Z1, 2 ; Mortazavian E3 ; Rafieetehrani N4 ; Behmadi H5 ; Rafieetehrani M3 ; Moosavimovahedi AA6
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Source: International Journal of Biological Macromolecules Published:2018


Abstract

This study aims at the mathematical optimization by Box-Behnken statistical design, fabrication by ionic gelation technique and in vitro characterization of insulin nanoparticles containing thiolated N- dimethyl ethyl chitosan (DMEC-Cys) conjugate. Then Optimized insulin nanoparticles were loaded into the buccal film, and in-vitro drug release from films was investigated, and diffusion coefficient was predicted. The optimized nanoparticles were shown to have mean particle size diameter of 148 nm, zeta potential of 15.5 mV, PdI of 0.26 and AE of 97.56%. Cell viability after incubation with optimized nanoparticles and films were assessed using an MTT biochemical assay. In vitro release study, FTIR and cytotoxicity also indicated that nanoparticles made of this thiolated polymer are suitable candidates for oral insulin delivery. © 2018 Elsevier B.V.
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