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Metformin and Silymarin Loaded Onto Poly(Caprolactone)/Chitosan Polymeric Nanofiber Based Pads for Diabetic Wound Healing Publisher



Sepahdar A1 ; Rahnamafar R1, 2 ; Bahadorikhalili S3 ; Azadbakht K4 ; Eslami O5 ; Rezvanfar MA6 ; Rezaei G2 ; Javar HA5
Authors
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Authors Affiliations
  1. 1. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Institute of Chemical Research of Catalonia (ICIQ), Barcelona Institute of Science and Technology, Avenida Paisos Catalans 16, Tarragona, 43007, Spain
  4. 4. Department of Prosthodontics, Faculty of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran
  5. 5. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran

Source: New Journal of Chemistry Published:2024


Abstract

Diabetes is one of the most prevalent genetic-metabolic diseases worldwide, affecting a significant number of individuals from diverse communities. One of its major complications is diabetic foot ulcers, resulting from several factors including peripheral vascular damage and an impaired immune system. In recent years, various approaches have been proposed for the treatment of diabetic foot ulcers. Among the innovative strategies, the utilization of advanced drug delivery systems has gained considerable attention. Nanofibers based on biocompatible and biodegradable polymers have been extensively studied for drug delivery and tissue engineering applications. Chitosan/poly(caprolactone) nanofibers have been investigated in various studies for targeted drug delivery, including in the context of diabetes. In this research, chitosan/poly(caprolactone) nanofibers loaded with metformin and silymarin were prepared and evaluated for their physicochemical properties and cellular toxicity. The nanofibers exhibited a size of less than 200 nanometers and possessed sufficient mechanical strength. The synergistic effects of metformin and silymarin encapsulated within chitosan/poly(caprolactone) nanofibers were studied for the treatment of diabetic foot ulcers. Drug release studies demonstrated an initial burst release followed by sustained and controlled release over an extended period. Cellular toxicity results indicated the biocompatibility of the nanofibers, making them suitable candidates for animal and clinical studies. Overall, chitosan/poly(caprolactone) nanofibers exhibited desirable physicochemical characteristics, and their biocompatibility and biodegradability properties enhance their potential for clinical applications. © 2024 The Royal Society of Chemistry
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