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The Gene Manipulation and Cellular Immunotherapy Combination in the Treatment of Cancer Publisher



Khatami F1 ; Aghamir ZS2 ; Jahanshahi F3 ; Feizabadi SA1 ; Birang F4 ; Khoshchehreh M5 ; Shabestari AN6 ; Aghamir SMK1
Authors
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Authors Affiliations
  1. 1. Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Laboratory Sciences, Allied Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathology, University of California, Los Angeles, Los Angeles, United States
  6. 6. Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Biotechnology Published:2022


Abstract

Context: The immune system is directly linked to the tumors, from tumor formation to the tumor’s development and metastasis. So, the interest of scientists over the protective immunological mechanisms has increased and shown gifted strategy in cancer treatment. Evidence acquisition: Genetic engineering and cellular immunotherapy are two different advanced molecular mechanisms to modify the immune responses and genome. Gene manipulation is the bioengineering technology that allows vectors to transfer new genetic information into the target cells. Cellular immunotherapy is an excellent strategy that connects the body’s immune system to fight cancer. Results & Conclusions: This review described that combination of genetic engineering and cellular immunotherapy has brought the novel antitumor repressive molecules stopping the tumor tissue immune tolerance and significantly expanding cancer therapy’s effectiveness. Usually, cell immunotherapy and genetic engineering are considered two independent processes, and, in this review, we believe them in combinations. Here, we review these two novel approaches, and they are both combinations in terms of technological advances and clinical experience. © 2022 The Author(s).
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