Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum

Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum Publisher

Valadbeigi H¹ ; Khoshnood S¹ ; Negahdari B² ; Maleki A¹ ; Mohammadinejat M³ ; Haddadi MH¹

Show Affiliations

1. Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Chemistry, North-Tehran Branch, Islamic Azad University, Tehran, Iran

Source: Oral Diseases Published:2023

Abstract

Background: Fusobacterium nucleatum (F. nucleatum) is an integral component of supra- and subgingival biofilms, especially more prevalent in subgingival areas during both periodontal health and disease. Aims: In this review, we explore the physical, metabolic, and genetic interactions that influence the role of F. nucleatum in the formation of mixed oral biofilms. The role of F. nucleatum in antibiotic resistance in oral biofilms was discussed and some therapeutic strategies were proposed. Methods: PubMed, Scopus, Google Scholar, and the Web of Science were extensively searched for English-language reports. Results: F. nucleatum-derived proteins such as RadD, Fap2, FomA, and CmpA are involved in direct interactions contributing to biofilm formation, while autoinducer-2 and putrescine are involved in metabolic interactions. Both groups are essential for the formation and persistence of oral biofilms. This study highlights the clinical relevance of targeted interactions of F. nucleatum in supra- and subgingival oral biofilms. Conclusions: By focusing on these interactions, researchers and clinicians can develop more effective strategies to prevent biofilm-related disease and reduce the spread of antibiotic resistance. Further research in this area is warranted to explore the potential therapeutic interventions that can be derived from understanding the interactions of F. nucleatum in oral biofilm dynamics. © 2023 Wiley Periodicals LLC.

Style	Citing Format
MLA	Valadbeigi H, et al.. "Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum." Oral Diseases, vol. , no. , 2023, pp. -.
APA	Valadbeigi H, Khoshnood S, Negahdari B, Maleki A, Mohammadinejat M, Haddadi MH (2023). Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum. Oral Diseases, (), -.
Chicago	Valadbeigi H, Khoshnood S, Negahdari B, Maleki A, Mohammadinejat M, Haddadi MH. "Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum." Oral Diseases , no. (2023): -.
Harvard	Valadbeigi H et al. (2023) 'Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum', Oral Diseases, (), pp. -.
Vancouver	Valadbeigi H, Khoshnood S, Negahdari B, Maleki A, Mohammadinejat M, Haddadi MH. Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum. Oral Diseases. 2023;():-.
BibTex	@article{ author = {Valadbeigi H and Khoshnood S and Negahdari B and Maleki A and Mohammadinejat M and Haddadi MH}, title = {Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum}, journal = {Oral Diseases}, volume = {}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Valadbeigi H AU - Khoshnood S AU - Negahdari B AU - Maleki A AU - Mohammadinejat M AU - Haddadi MH TI - Mixed Oral Biofilms Are Controlled by the Interspecies Interactions of Fusobacterium Nucleatum JO - Oral Diseases VL - IS - SP - EP - PY - 2023 ER -

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Abstract