The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats

The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats Publisher Pubmed

Sadeghi S¹ ; Delphan M² ; Shams M¹ ; Esmaeili F³ ; Shanakibavarsad M⁴ ; Shanaki M¹

Show Affiliations

1. Department of Medical Laboratory Sciences, School of Allied Medical Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Alzahra University, Tehran, Iran
3. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, United States

Source: BMC Research Notes Published:2023

Abstract

Objective: Targeting autophagy is a new therapeutic strategy for the complications of diabetes,such as diabetic cardiomyopathy (DCM). During diabetes, increased or insufficient autophagic activity causes aberrations in cellular homeostasis. Regarding the conflicting and unclear results regarding the effect of HIIT and curcumin supplementation on the expression of genes associated to autophagy, this study aimed to assess whether 4-week high-intensity interval training (HIIT) and curcumin supplementation are able to influence the expression of autophagy-related genes in myocardial cells of diabetic rats. Methods: In an experimental design, 24 male Wistar rats were randomly divided into 4 groups: non-diabetic control (NC), diabetic control (DC), diabetes + HIIT (D + HIIT), and diabetes + curcumin (D + CU). After HIIT program and curcumin treatment, the genes expression of autophagy pathway were assessed in the myocardium by real-time PCR Tanique. Results: The results indicated that the expression levels of ATG1, Beclin1, ATG5, and LAMP-2 genes were significantly reduced in the DC group compared to the NC group (p < 0.001). Following 4-week HIIT, the expression of Beclin1, ATG-5, and LAMP-2 improved considerably compared to the DC group (p < 0.001, p < 0.001, and p < 0.05, respectively). In addition, after 4 weeks of curcumin supplementation, the expression levels of ATG-5 and Beclin-1 were significantly improved compared to the DC group (p < 0.001, p < 0.05, respectively). It seems HIIT and curcumin supplementation can be an effective approach for inducing autophagy and improving cardiac function in DCM rats.However, HIIT seems more effective than curcumin in this regard. © 2023, The Author(s).

Related Docs

View other Related Docs

1. Crosstalk Between Autophagy and Insulin Resistance: Evidence From Different Tissues, European Journal of Medical Research (2023)

2. Autophagy: A Challengeable Paradox in Cancer Treatment, Cancer Medicine (2023)

3. The Role of Autophagy in Cancer: From Molecular Mechanism to Therapeutic Window, Frontiers in Immunology (2025)

4. Nano-Curcumin Improves Glucose Indices, Lipids, Inflammation, and Nesfatin in Overweight and Obese Patients With Non-Alcoholic Fatty Liver Disease (Nafld): A Double-Blind Randomized Placebo-Controlled Clinical Trial, Nutrition and Metabolism (2019)

5. Regulation of Autophagy by Non-Coding Rnas in Human Glioblastoma, Medical Oncology (2024)

6. Virus, Exosome, and Microrna: New Insights Into Autophagy, Advances in Experimental Medicine and Biology (2022)

7. Diabetes and Heart Failure: Multi-Omics Approaches, Frontiers in Physiology (2021)

8. The C1q/Tnf-Related Proteins (Ctrps) in Pathogenesis of Obesity-Related Metabolic Disorders: Focus on Type 2 Diabetes and Cardiovascular Diseases, Life Sciences (2020)

Experts (# of related papers)

View all Related Experts

Hamid Reza Mirzaei (1)

Seyed Mahdi Rezayat Sorkhabadi (1)

Style	Citing Format
MLA	Sadeghi S, et al.. "The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats." BMC Research Notes, vol. 16, no. 1, 2023, pp. -.
APA	Sadeghi S, Delphan M, Shams M, Esmaeili F, Shanakibavarsad M, Shanaki M (2023). The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats. BMC Research Notes, 16(1), -.
Chicago	Sadeghi S, Delphan M, Shams M, Esmaeili F, Shanakibavarsad M, Shanaki M. "The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats." BMC Research Notes 16, no. 1 (2023): -.
Harvard	Sadeghi S et al. (2023) 'The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats', BMC Research Notes, 16(1), pp. -.
Vancouver	Sadeghi S, Delphan M, Shams M, Esmaeili F, Shanakibavarsad M, Shanaki M. The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats. BMC Research Notes. 2023;16(1):-.
BibTex	@article{ author = {Sadeghi S and Delphan M and Shams M and Esmaeili F and Shanakibavarsad M and Shanaki M}, title = {The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats}, journal = {BMC Research Notes}, volume = {16}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Sadeghi S AU - Delphan M AU - Shams M AU - Esmaeili F AU - Shanakibavarsad M AU - Shanaki M TI - The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats JO - BMC Research Notes VL - 16 IS - 1 SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract