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Regulation of Autophagy by Non-Coding Rnas in Human Glioblastoma Publisher Pubmed



Molavand M1 ; Ebrahimnezhade N2 ; Kiani A3 ; Yousefi B2, 4 ; Nazari A2, 5 ; Majidinia M6
Authors
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Authors Affiliations
  1. 1. Student Research Commitee, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran
  3. 3. Student Research Commite, Yasuj University of Medical Sciences, Yasuj, Iran
  4. 4. Molecular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Solid Tumor Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran

Source: Medical Oncology Published:2024


Abstract

Glioblastoma, a lethal form of brain cancer, poses substantial challenges in treatment due to its aggressive nature and resistance to standard therapies like radiation and chemotherapy. Autophagy has a crucial role in glioblastoma progression by supporting cellular homeostasis and promoting survival under stressful conditions. Non-coding RNAs (ncRNAs) play diverse biological roles including, gene regulation, chromatin remodeling, and the maintenance of cellular homeostasis. Emerging evidence reveals the intricate regulatory mechanisms of autophagy orchestrated by non-coding RNAs (ncRNAs) in glioblastoma. The diverse roles of these ncRNAs in regulating crucial autophagy-related pathways, including AMPK/mTOR signaling, the PI3K/AKT pathway, Beclin1, and other autophagy-triggering system regulation, sheds light on ncRNAs biological mechanisms in the proliferation, invasion, and therapy response of glioblastoma cells. Furthermore, the clinical implications of targeting ncRNA-regulated autophagy as a promising therapeutic strategy for glioblastoma treatment are in the spotlight of ongoing studies. In this review, we delve into our current understanding of how ncRNAs regulate autophagy in glioblastoma, with a specific focus on microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), and their intricate interplay with therapy response. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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