Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
High Intensity Interval Training Improves Diabetic Cardiomyopathy Via Mir-1 Dependent Suppression of Cardiomyocyte Apoptosis in Diabetic Rats Publisher



Delfan M1 ; Delphan M2 ; Kordi MR3 ; Ravasi AA3 ; Safa M4, 5 ; Gorganifiruzjaee S6 ; Fatemi A7, 8 ; Bandarian F9 ; Nasliesfahani E10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran
  2. 2. Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran
  4. 4. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Hematology, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Medical Laboratory Sciences, School of Allied Health Medicine, AJA University of Medical sciences, Tehran, Iran
  7. 7. Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran
  8. 8. Department Hematology, School of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran
  9. 9. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, 5th floor, Shariati Hopital, North Kargar Ave., Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2020


Abstract

Purpose: Diabetes and its complications such as diabetic cardiomyopathy still account for significant morbidity and mortality. High-quality evidence was shown the importance of exercise in controlling diabetes complications, but the molecular mechanism on diabetic cardiomyopathy is not yet fully understood. This study aimed to compare and investigate the effect of high intensity interval training (HIIT) and continuous endurance training (CET) on the signaling pathway of diabetic cardiomyopathy. Methods: Hence, 21 Wistar rats with an average weight of 260 ± 10 g, after induction of diabetes (STZ 50 mg/kg BW) were randomly divided into three groups (control, CET and HIIT; n = 7). Training programs were conducted 5 days a week for 5 weeks. CET program was defined as running at 60% vVO2max for 30 min in each session and the HIIT program was defined as running at 85–90% vVO2max for 3 min followed by 1 min recovery (30–35% vVO2max), that was repeated four times in each session. The cardiac performance was analyzed via determination of end systolic and diastolic dimensions and the ejection fraction by echocardiography. To elucidate the responsible molecular mechanism of miR-1, IGF-1 and IGF-1R mRNA and apoptosis marker protein expression were investigated. Results: Both training programs specifically HIIT, significantly reduced the blood glucose, enhanced heart performance, reduced miR-1 expression, induced IGF-1 and IGF-1R expression and reduced apoptotic protein expression. Conclusion: We showed that HIIT is more effective than CET for reduction of diabetic cardiomyopathy as a complication of diabetes in animal models through suppressing miR-1 and its downstream apoptosis pathway. © 2020, Springer Nature Switzerland AG.
Related Docs
View other Related Docs
1. The Role of Micrornas in the Regulation of Insulin Signaling Pathway With Respect to Metabolic and Mitogenic Cascades: A Review, Journal of Cellular Biochemistry (2019)
2. Acetylation and Insulin Resistance: A Focus on Metabolic and Mitogenic Cascades of Insulin Signaling, Critical Reviews in Clinical Laboratory Sciences (2020)
3. Aerobic Endurance Training Improves Nonalcoholic Fatty Liver Disease (Nafld) Features Via Mir-33 Dependent Autophagy Induction in High Fat Diet Fed Mice, Obesity Research and Clinical Practice (2018)
4. Palmitate-Induced Impairment of Autophagy Turnover Leads to Increased Apoptosis and Inflammation in Peripheral Blood Mononuclear Cells, Immunobiology (2018)
5. The High-Intensity Interval Training (Hiit) and Curcumin Supplementation Can Positively Regulate the Autophagy Pathway in Myocardial Cells of Stz-Induced Diabetic Rats, BMC Research Notes (2023)
6. The Potential for Circulating Micrornas in the Diagnosis of Myocardial Infarction: A Novel Approach to Disease Diagnosis and Treatment, Current Pharmaceutical Design (2016)
7. Decreased Expression of Microrna-21 Is Associated With Increased Cytokine Production in Peripheral Blood Mononuclear Cells (Pbmcs) of Obese Type 2 Diabetic and Non-Diabetic Subjects, Molecular and Cellular Biochemistry (2016)
8. Decreased Serum Level of Mir-155 Is Associated With Obesity and Its Related Metabolic Traits, Clinical Laboratory (2018)
Experts (# of related papers)
View all Related Experts
Reza Meshkani (7)
Farideh Razi (2)
Other Related Docs
9. Carvedilol Alters Circulating Mir-1 and Mir-214 in Heart Failure, Pharmacogenomics and Personalized Medicine (2020)
10. Inhibition of Sh2-Domain-Containing Inositol 5-Phosphatase (Ship2) Ameliorates Palmitate Induced-Apoptosis Through Regulating Akt/Foxo1 Pathway and Ros Production in Hepg2 Cells, Biochemical and Biophysical Research Communications (2015)