Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors

Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors Publisher

Rayatzadeh A¹ ; Saeedi M³ ; Mahdavi M² ; Rezaei Z² ; Sabourian R³ ; Mosslemin MH¹ ; Akbarzadeh T^{2, 3} ; Foroumadi A² ; Shafiee A²

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1. Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176, Iran
3. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Monatshefte fur Chemie Published:2015

Abstract

An efficient synthetic route for the synthesis of novel oxoisoindoline derivatives was described through Ugi reaction of 2-formylbenzoic acids, amines, and isocyanides. All compounds were evaluated for their acetylcholinesterase inhibitory activity and among them, 2 of 12 tested compounds showed good activity as compared to other derivatives. Graphical Abstract: [Figure not available: see fulltext.]. © 2014 Springer-Verlag Wien.

Style	Citing Format
MLA	Rayatzadeh A, et al.. "Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors." Monatshefte fur Chemie, vol. 146, no. 4, 2015, pp. 637-643.
APA	Rayatzadeh A, Saeedi M, Mahdavi M, Rezaei Z, Sabourian R, Mosslemin MH, Akbarzadeh T, Foroumadi A, Shafiee A (2015). Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors. Monatshefte fur Chemie, 146(4), 637-643.
Chicago	Rayatzadeh A, Saeedi M, Mahdavi M, Rezaei Z, Sabourian R, Mosslemin MH, Akbarzadeh T, Foroumadi A, Shafiee A. "Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors." Monatshefte fur Chemie 146, no. 4 (2015): 637-643.
Harvard	Rayatzadeh A et al. (2015) 'Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors', Monatshefte fur Chemie, 146(4), pp. 637-643.
Vancouver	Rayatzadeh A, Saeedi M, Mahdavi M, Rezaei Z, Sabourian R, Mosslemin MH, et al.. Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors. Monatshefte fur Chemie. 2015;146(4):637-643.
BibTex	@article{ author = {Rayatzadeh A and Saeedi M and Mahdavi M and Rezaei Z and Sabourian R and Mosslemin MH and Akbarzadeh T and Foroumadi A and Shafiee A}, title = {Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors}, journal = {Monatshefte fur Chemie}, volume = {146}, number = {4}, pages = {637-643}, year = {2015} }
RIS	TY - JOUR AU - Rayatzadeh A AU - Saeedi M AU - Mahdavi M AU - Rezaei Z AU - Sabourian R AU - Mosslemin MH AU - Akbarzadeh T AU - Foroumadi A AU - Shafiee A TI - Synthesis and Evaluation of Novel Oxoisoindoline Derivatives As Acetylcholinesterase Inhibitors JO - Monatshefte fur Chemie VL - 146 IS - 4 SP - 637 EP - 643 PY - 2015 ER -

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