Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Potential Use of Therapeutics and Prophylactic Mrna Vaccines in Human Papillomavirus (Hpv) Publisher Pubmed



Movahed F1 ; Darzi S2 ; Mahdavi P3 ; Salih Mahdi M4 ; Qutaiba B Allela O5 ; Naji Sameer H6 ; Adil M7 ; Zarkhah H8 ; Yasamineh S9 ; Gholizadeh O10
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Gynecology and Obstetrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department Of Obstetrics and Gynecology, Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran
  3. 3. Department of Obstetrics and Gynecology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. College of MLT, Ahl Al Bayt University, Karbala, Iraq
  5. 5. Department of Pharmacy, Al-Noor University College, Nineveh, Iraq
  6. 6. Collage of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq
  7. 7. Pharmacy college, Al-Farahidi University, Baghdad, Iraq
  8. 8. Department of Obstetrics and Gynaecology, Tabriz University of Medical Siences, Tabriz, Iran
  9. 9. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran
  10. 10. Azad Researchers, Virology and Biotechnology, Tehran, Iran

Source: Virology Journal Published:2024


Abstract

Cervical cancer (CC) and other malignant malignancies are acknowledged to be primarily caused by persistent human papillomavirus (HPV) infection. Historically, vaccinations against viruses that produce neutralizing antibodies unique to the virus have been an affordable way to manage viral diseases. CC risk is decreased, but not eliminated, by HPV vaccinations. Since vaccinations have been made available globally, almost 90% of HPV infections have been successfully avoided. On the lesions and diseases that are already present, however, no discernible treatment benefit has been shown. As a result, therapeutic vaccines that elicit immune responses mediated by cells are necessary for the treatment of established infections and cancers. mRNA vaccines possess remarkable potential in combating viral diseases and malignancy as a result of their superior industrial production, safety, and efficacy. Furthermore, considering the expeditiousness of production, the mRNA vaccine exhibits promise as a therapeutic approach targeting HPV. Given that the HPV-encoded early proteins, including oncoproteins E6 and E7, are consistently present in HPV-related cancers and pre-cancerous lesions and have crucial functions in the progression and persistence of HPV-related diseases, they serve as ideal targets for therapeutic HPV vaccines. The action mechanism of HPV and HPV-related cancer mRNA vaccines, their recent advancements in clinical trials, and the potential for their therapeutic applications are highlighted in this study, which also offers a quick summary of the present state of mRNA vaccines. Lastly, we highlight a few difficulties with mRNA HPV vaccination clinical practice and provide our thoughts on further advancements in this quickly changing sector. It is expected that mRNA vaccines will soon be produced quickly for clinical HPV prevention and treatment. Graphical Abstract: (Figure presented.) © The Author(s) 2024.
Related Docs
View other Related Docs
1. Mrna Cancer Vaccines From Bench to Bedside: A New Era in Cancer Immunotherapy, Biomarker Research (2024)
2. The Potential Use of Bacteria and Bacterial Derivatives As Drug Delivery Systems for Viral Infection, Virology Journal (2023)
3. The Clinical Impact of Mrna Therapeutics in the Treatment of Cancers, Infections, Genetic Disorders, and Autoimmune Diseases, Heliyon (2024)
4. Delving Into Revolutionary Sars-Cov-2 Vaccine Approaches: Molecular and Virological Examinations; Principles of Sars-Cov-2 Vaccine Platform; [Adentrandose En Enfoques Revolucionarios De Vacunas Sars-Cov-2: Examenes Moleculares Y Virologicos; Principios De La Plataforma De Vacunas Sars-Cov-2], Vacunas (2024)
5. The Potential Use of Bacteria and Their Derivatives As Delivery Systems for Nanoparticles in the Treatment of Cancer, Journal of Drug Targeting (2025)
6. Characterization of Stability, Safety and Immunogenicity of the Mrna Lipid Nanoparticle Vaccine Iribovax® Against Covid-19 in Nonhuman Primates, Journal of Controlled Release (2023)
7. Recent Advances in Metal Nanoparticles to Treat Periodontitis, Journal of Nanobiotechnology (2023)
8. Recent Advances on High-Efficiency of Micrornas in Different Types of Lung Cancer: A Comprehensive Review, Cancer Cell International (2023)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (4)
Mohammad Hossein Modarressi (3)
Other Related Docs
9. Could Artificial Intelligence Revolutionize the Development of Nanovectors for Gene Therapy and Mrna Vaccines?, Nano Today (2022)
10. Design and Development of Modified Mrna Encoding Core Antigen of Hepatitis C Virus: A Possible Application in Vaccine Production, Iranian Biomedical Journal (2019)
11. Therapeutic and Diagnostic Applications of Nanoparticles in the Management of Covid-19: A Comprehensive Overview, Virology Journal (2022)
12. The Role of Dental-Derived Stem Cell-Based Therapy and Their Derived Extracellular Vesicles in Post-Covid-19 Syndrome-Induced Tissue Damage, Stem Cell Reviews and Reports (2024)
13. Progress and Prospects on Vaccine Development Against Monkeypox Infection, Microbial Pathogenesis (2023)
14. Immunotherapy a New Hope for Cancer Treatment: A Review, Pakistan Journal of Biological Sciences (2018)
15. Spotlight on Therapeutic Efficiency of Green Synthesis Metals and Their Oxide Nanoparticles in Periodontitis, Journal of Nanobiotechnology (2024)
16. Cancer Immunoprevention: Current Status and Future Directions, Archivum Immunologiae et Therapiae Experimentalis (2021)
17. Vaccine Design and Delivery Approaches for Covid-19, International Immunopharmacology (2021)
18. Emerging Paradigms: Unmasking the Role of Oxidative Stress in Hpv-Induced Carcinogenesis, Infectious Agents and Cancer (2024)
19. Long-Term Vaccine Delivery and Immunological Responses Using Biodegradable Polymer-Based Carriers, ACS Applied Bio Materials (2022)
20. Prophylactic Vaccines Against Hpv-Caused Cervical Cancer: Novel Vaccines Are Still Demanded, Infectious Agents and Cancer (2025)
21. A State-Of-The-Art Review of the Recent Advances in Exosome Isolation and Detection Methods in Viral Infection, Virology Journal (2024)
22. Smart Biomaterials to Enhance the Efficiency of Immunotherapy in Glioblastoma: State of the Art and Future Perspectives, Advanced Drug Delivery Reviews (2021)
23. Distribution of Human Papillomavirus Genotypes in Suspected Women Cytological Specimens From Tehran, Iran, Iranian Journal of Microbiology (2022)
24. Spotlight on the Impact of Viral Infections on Hematopoietic Stem Cells (Hscs) With a Focus on Covid-19 Effects, Cell Communication and Signaling (2023)
25. Gene Therapy to Enhance Angiogenesis in Chronic Wounds, Molecular Therapy Nucleic Acids (2022)
26. The Role of Bismuth Nanoparticles in the Inhibition of Bacterial Infection, World Journal of Microbiology and Biotechnology (2023)
27. Influenza Vaccine: Where Are We and Where Do We Go?, Reviews in Medical Virology (2019)
28. Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis, Current Microbiology (2023)
29. An Overview on Papillomaviruses As the Main Cause of Cervical Cancer, Iranian Journal of Obstetrics# Gynecology and Infertility (2015)
30. Gene Therapy and Genetic Vaccines, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
31. Combining Anti-Checkpoint Immunotherapies and Cancer Vaccines As a Novel Strategy in Oncological Therapy: A Review, Human Immunology (2025)
32. Dna Vaccines As Promising Immuno-Therapeutics Against Cancer: A New Insight, Frontiers in Immunology (2024)
33. Immunogenicity and Safety of a Bivalent, Adjuvant System 04-Adjuvanted Human Papillomavirus Vaccine in Healthy Female Volunteers Aged 15-25: A Randomized, Double-Blind, Phase Iii, Noninferiority Clinical Trial, European Journal of Cancer Prevention (2022)
34. Potential Role of Metal Nanoparticles in Treatment of Peri-Implant Mucositis and Peri-Implantitis, BioMedical Engineering Online (2024)
35. Polymeric Nanoparticles for Dna Vaccine-Based Cancer Immunotherapy: A Review, Biotechnology Letters (2023)
36. Current Advances and Challenges in Covid-19 Vaccine Development: From Conventional Vaccines to Next-Generation Vaccine Platforms, Molecular Biology Reports (2022)
37. The Significance of Bioengineered Nanoplatforms Against Sars-Cov-2: From Detection to Genome Editing, Life Sciences (2021)
38. Mesenchymal Stem Cell-Based Scaffolds in Regenerative Medicine of Dental Diseases, Stem Cell Reviews and Reports (2024)
39. The Therapeutic Effect of Mrna Vaccines in Glioma: A Comprehensive Review, Expert Review of Clinical Immunology (2025)
40. Comparison of Immune Response Between Sars, Mers, and Covid-19 Infection, Perspective on Vaccine Design and Development, BioMed Research International (2021)