A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges

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A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges Publisher Pubmed

P Vosoughi PEGAH ; Sm Naghib Seyed MORTEZA ; M Rahmanian MEHDI ; Mr Mozafari M R

Source: Current Topics in Medicinal Chemistry Published:2025

Abstract

Ongoing research and development efforts are currently focused on creating COVID-19 vaccines using a variety of platforms. Among these, mRNA technology stands out as a cutting-edge method for vaccine development. There is a growing public awareness of mRNA and its potential in vaccine development. Despite being relatively recent, extensive scientific research has been dedicated to vaccines for a considerable period. mRNA vaccines are created by synthesizing the spike protein from a DNA template. This review delves into the various aspects of these vaccines and thoroughly explores the intricacies of COVID-19 vaccinations. It is essential to choose a reliable, efficient, and widely accessible vaccine to combat COVID-19. However, due to the possibility of virus mutations, developing a dependable and safe vaccine is crucial to prepare for future outbreaks of SARS-CoV-2 variants. Meanwhile, concerns remain regarding the potential risks associated with these vaccines. © 2025 Elsevier B.V., All rights reserved.

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Style	Citing Format
MLA	P Vosoughi PEGAH, et al.. "A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges." Current Topics in Medicinal Chemistry, vol. 25, no. 12, 2025, pp. 1467-1491.
APA	P Vosoughi PEGAH, Sm Naghib Seyed MORTEZA, M Rahmanian MEHDI, Mr Mozafari M R (2025). A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges. Current Topics in Medicinal Chemistry, 25(12), 1467-1491.
Chicago	P Vosoughi PEGAH, Sm Naghib Seyed MORTEZA, M Rahmanian MEHDI, Mr Mozafari M R. "A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges." Current Topics in Medicinal Chemistry 25, no. 12 (2025): 1467-1491.
Harvard	P Vosoughi PEGAH et al. (2025) 'A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges', Current Topics in Medicinal Chemistry, 25(12), pp. 1467-1491.
Vancouver	P Vosoughi PEGAH, Sm Naghib Seyed MORTEZA, M Rahmanian MEHDI, Mr Mozafari M R. A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges. Current Topics in Medicinal Chemistry. 2025;25(12):1467-1491.
BibTex	@article{ author = {P Vosoughi PEGAH and Sm Naghib Seyed MORTEZA and M Rahmanian MEHDI and Mr Mozafari M R}, title = {A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges}, journal = {Current Topics in Medicinal Chemistry}, volume = {25}, number = {12}, pages = {1467-1491}, year = {2025} }
RIS	TY - JOUR AU - P Vosoughi PEGAH AU - Sm Naghib Seyed MORTEZA AU - M Rahmanian MEHDI AU - Mr Mozafari M R TI - A Comprehensive Review of Mrna-Based Vaccines for Covid-19, a New Era in Pharmaceuticals: Unspecified and Unknown Aspects, Effects and Challenges JO - Current Topics in Medicinal Chemistry VL - 25 IS - 12 SP - 1467 EP - 1491 PY - 2025 ER -

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