Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Effect of Garlic on Vascular Function: A Systematic Review of Randomized Clinical Trials Publisher Pubmed



Emamat H1 ; Tangestani H2 ; Totmaj AS3 ; Ghalandari H4 ; Nasrollahzadeh J5
Authors

Source: Clinical Nutrition Published:2020


Abstract

Backgrounds and aims: Atherosclerosis and its associated cardiovascular disease (CVD) represent a major global health problem worldwide and vascular dysfunction is important in its pathogenesis. Clinical trials investigating the effect of garlic on vascular function measured by several non-invasive methods and their results are inconsistent. This study aimed to summarize the current evidence regarding the effectiveness of garlic as one of the world's most ancient medicines on measures of vascular reactivity and/or stiffness in adults. Methods: All published RCTs in English were systematically searched on PubMed, Scopus and Google Scholar search engines up to Oct 2019. The exposure and outcome variable of interest were garlic and vascular function measurements. Ten trials which met inclusion criteria were included in this study. Results: A total of 45 studies were found through search databases. After excluding duplicates, the 25 remaining studies were screened by title and abstract which 15 of them excluded. Finally, ten trials were included in this review study, which were published between 2004 and 2018. Conclusions: Findings were inconsistent. However, garlic has the potential to improve vascular function, particularly in subjects with cardiovascular risk factors. Additional human studies on garlic and its constituents should consider the population and the specific type of garlic preparation. © 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
Other Related Docs
6. Bioactive Compounds and Biological Activities of Allium Sativum L., Reference Series in Phytochemistry (2024)
7. Aged Garlic and Cancer: A Systematic Review, International Journal of Preventive Medicine (2018)