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Randomized, Double-Blind Clinical Trial Evaluating the Impact of Freeze-Dried Garlic Extract Capsules on Blood Pressure, Lipid Profile, and Nitric Oxide Levels in Individuals at Risk for Hypertension Publisher Pubmed



E Rahmatinia ELHAM ; B Amidi BARDIA ; N Naderi NARGES ; S Ahmadipour SAEEDEH ; H Ahmadvand HASSAN ; Mt Pahlevanfallahy Mohammad TAHA ; V Ghorbanzadeh VAJIHE ; A Nazari AFSHIN
Authors

Source: Hormone Molecular Biology and Clinical Investigation Published:2024


Abstract

Hypertension, substantially heightens the risk of cardiovascular disease. This study aims to evaluate the effectiveness of freeze-dried garlic extract in blood pressure and lipid profiles in prehypertensive individuals. Participants (age of 30-70 years) were allocated to intervention (n=47) or control (n=49) groups. The intervention group received two capsules of freeze-dried garlic extract daily for eight weeks, while the control group received identical placebo capsules. Primary outcomes, SBP, DBP, PP, MAP, TC, TG, LDL and HDL levels, serum NO levels, were assessed at baseline, four weeks, and eight weeks. At the end of study, results showed significant changes in the values of SBP, DBP, and MAP except for PP. In comparison to those who received the placebo, a significant drop in SBP, DBP (p<0.001), and MAP (p<0.001) was observed in the intervention group. Also, there were significant changes in TG, LDL, TC, and HDL levels in the interventional group. A noticeable decline was reported in TG (p<0.001), LDL (p<0.001), and TC (p<0.001), while HDL levels increased (p<0.001) in the intervention group compared to those receiving the placebo. Following garlic supplementation, a significant increase in blood NO levels was reported in the intervention group (p<0.001). The study showed that garlic supplementation was effective in lowering blood pressure, improving lipid profile, and increasing nitric oxide levels in prehypertensive participants. These results indicate that garlic could be a valuable complementary therapy for managing prehypertension. © 2024 Elsevier B.V., All rights reserved.
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