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Glutamine Supplementation Enhances the Effects of a Low Fodmap Diet in Irritable Bowel Syndrome Management Publisher



Rastgoo S1 ; Ebrahimidaryani N2 ; Agah S3 ; Karimi S2 ; Taher M2 ; Rashidkhani B1 ; Hejazi E1 ; Mohseni F1 ; Ahmadzadeh M1 ; Sadeghi A4 ; Hekmatdoost A1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Nutrition Published:2021


Abstract

Background and Aims: Although irritable bowel syndrome is one of the most common gastrointestinal disorders presented to gastroenterologists, therapeutic strategies are not yet well-established. Accordingly, we conducted a randomized, double-blind, placebo-controlled, clinical trial to evaluate the possible superiority of adding glutamine supplement to low fermentable oligo- di- monosaccharides and polyols (FODMAP) diet in patients with irritable bowel syndrome (IBS). Methods: Eligible adults were randomized to receive a low FODMAP diet either with glutamine (15 g/day) or a placebo for 6 weeks. The primary endpoint was a significant reduction in IBS-symptom severity score (IBS-SSS). Secondary endpoints were changes in IBS symptoms, stool frequency, consistency, and quality of life. Results: The study group enrolled 50 patients, among which 22 participants from each group completed the study protocol. The glutamine group had significant changes in total IBS-severity score, dissatisfaction of bowel habit and interference with community function (58% reduction; P < 0.001, 57% reduction; P < 0.001, 51% reduction; P = 0.043, respectively). Improvement in IBS-severity score of more than 45% was observed in 22 of 25 participants (88%) in the glutamine group, while it was only 15 of 25 participants (60%) in the control group (p = 0.015). No serious adverse events were observed. Conclusions: Our findings indicated the superiority of adding glutamine supplementation to a low FODMAP diet in amelioration of IBS symptoms while confirming the beneficial effects of a low FODMAP diet in IBS management. Copyright © 2021 Rastgoo, Ebrahimi-Daryani, Agah, Karimi, Taher, Rashidkhani, Hejazi, Mohseni, Ahmadzadeh, Sadeghi and Hekmatdoost.
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