Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc

Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc Publisher

Ahmadi H¹ ; Hosseinpour R¹ ; Jahanbin B² ; Majidzadeha K³ ; Azmoudehardalan F²

Show Affiliations

1. Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Genetics, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Archives of Breast Cancer Published:2020

Abstract

Background: Triple-negative subtype does not have any of the receptors that are commonly found in breast cancer. Patients suffering from Triple-negative breast cancer are at risk of early metastasis and BRCA mutation. The conversion of the receptors during the metastatic progression or local recurrence of breast cancer is a well-known topic that affects the therapeutic measures and outcome. Confirmation of immunohistochemistry is essential in these conditions, but genetic evaluation is controversial. Case presentation: A woman suffering from primary luminal breast cancer presented with femoral bone metastasis in the follow-up after two years. Bone metastasis was compatible with the triple-negative subtype. This case was discussed at the weekly breast multidisciplinary team session of the Department of Breast Surgery, Tehran University of Medical Sciences. Question: Does the patient need genetics counseling in a conversion setting? And does the new specimen need CISH/FISH techniques to confirm TNBC tumors? Conclusion: There are no strong guidelines to recommend genetic counseling and BRCA testing for patients with breast cancer biomarkers conversion. Reassessing the specimen for ER, PR, and HER-2 is necessary for this setting. © 2020 Farname Scientific Publishing Inc.

Style	Citing Format
MLA	Ahmadi H, et al.. "Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc." Archives of Breast Cancer, vol. 7, no. 1, 2020, pp. 10-13.
APA	Ahmadi H, Hosseinpour R, Jahanbin B, Majidzadeha K, Azmoudehardalan F (2020). Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc. Archives of Breast Cancer, 7(1), 10-13.
Chicago	Ahmadi H, Hosseinpour R, Jahanbin B, Majidzadeha K, Azmoudehardalan F. "Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc." Archives of Breast Cancer 7, no. 1 (2020): 10-13.
Harvard	Ahmadi H et al. (2020) 'Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc', Archives of Breast Cancer, 7(1), pp. 10-13.
Vancouver	Ahmadi H, Hosseinpour R, Jahanbin B, Majidzadeha K, Azmoudehardalan F. Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc. Archives of Breast Cancer. 2020;7(1):10-13.
BibTex	@article{ author = {Ahmadi H and Hosseinpour R and Jahanbin B and Majidzadeha K and Azmoudehardalan F}, title = {Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc}, journal = {Archives of Breast Cancer}, volume = {7}, number = {1}, pages = {10-13}, year = {2020} }
RIS	TY - JOUR AU - Ahmadi H AU - Hosseinpour R AU - Jahanbin B AU - Majidzadeha K AU - Azmoudehardalan F TI - Genetic Counseling in the Follow-Up of Breast Cancer Patients; Conversion of a Luminal Tumor to Tnbc JO - Archives of Breast Cancer VL - 7 IS - 1 SP - 10 EP - 13 PY - 2020 ER -

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