B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency

B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency Publisher

Bagheri Y^{1, 2} ; Moeini Shad T^{3, 4} ; Namazi S⁵ ; Tofighi Zavareh F^{3, 6} ; Azizi G⁷ ; Salami F^{3, 4} ; Sadani S⁸ ; Hosseini A⁸ ; Saeidi M^{2, 9} ; Pashangzadeh S³ ; Delavari S^{3, 4} ; Mirminachi B¹⁰ ; Rezaei N^{3, 11, 12} ; Abolhassani H^{3, 13} Show All Authors

Bagheri Y^{1, 2}
Moeini Shad T^{3, 4}
Namazi S⁵
Tofighi Zavareh F^{3, 6}
Azizi G⁷
Salami F^{3, 4}
Sadani S⁸
Hosseini A⁸
Saeidi M^{2, 9}
Pashangzadeh S³
Delavari S^{3, 4}
Mirminachi B¹⁰
Rezaei N^{3, 11, 12}
Abolhassani H^{3, 13}
Aghamohammadi A³
Yazdani R^{3, 4, 13, 14}

Show Affiliations

1. Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran
2. Department of Immunology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Childrenâ€™s Medical Center Hospital, Tehran University of Medical Sciences, 62 Qarib St., Keshavarz Blvd., Tehran, 14194, Iran
4. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
5. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
6. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
7. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
8. Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran
9. Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran
10. Division of Gastroenterology, Department of Medicine, Duke University, Durham, NC, United States
11. Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran
12. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
13. Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden
14. Department of Neurology, Thomas Jefferson University, Philadelphia, PA, United States

Source: Allergy# Asthma and Clinical Immunology Published:2023

Abstract

Background: Selective IgA deficiency (SIgAD) is the most prevalent inborn errors of immunity with almost unknown etiology. This study aimed to investigate the clinical diagnostic and prognostic values of lymphocyte subsets and function in symptomatic SIgAD patients. Methods: A total of 30 available SIgAD patients from the Iranian registry and 30 age-sex-matched healthy controls were included in the present study. We analyzed B and T cell peripheral subsets and T cell proliferation assay by flow cytometry in SIgAD patients with mild and severe clinical phenotypes. Results: Our results indicated a significant increase in naive and transitional B cells and a strong decrease in marginal zone-like and switched memory B-cells in SIgAD patients. We found that naive and central memory CD4+ T cell subsets, as well as Th1, Th2 and regulatory T cells, have significantly decreased. On the other hand, there was a significant reduction in central and effector memory CD8+ T cell subsets, whereas proportions of both (CD4+ and CD8+) terminally differentiated effector memory T cells (TEMRA) were significantly elevated in our patients. Although some T cell subsets in severe SIgAD were similar, a decrease in marginal-zone and switched memory B cells and an increase in CD21low B cell of severe SIgAD patients were slightly prominent. Moreover, the proliferation activity of CD4+ T cells was strongly impaired in SIgAD patients with a severe phenotype. Conclusion: SIgAD patients have varied cellular and humoral deficiencies. Therefore, T cell and B cell assessment might help in better understanding the heterogeneous pathogenesis and prognosis estimation of the disease. © 2023, The Author(s).

Related Docs

View other Related Docs

1. The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency, International Archives of Allergy and Immunology (2019)

2. Selective Iga Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management, Scandinavian Journal of Immunology (2017)

3. Immunophenotypic and Functional Analysis of Lymphocyte Subsets in Common Variable Immunodeficiency Patients Without Monogenic Defects, Scandinavian Journal of Immunology (2022)

4. Variable Abnormalities in T and B Cell Subsets in Ataxia Telangiectasia, Journal of Clinical Immunology (2021)

5. Evaluation of Specific Antibody Responses in Patients With Selective Iga Deficiency and Ataxia Telangiectasia, Endocrine# Metabolic and Immune Disorders - Drug Targets (2022)

6. Evaluation of Effective Factors on Il-10 Signaling in B Cells in Patients With Selective Iga Deficiency, European Cytokine Network (2021)

7. Atypical Ataxia Presentation in Variant Ataxia Telangiectasia: Iranian Case-Series and Review of the Literature, Frontiers in Immunology (2022)

8. Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management, Journal of Investigational Allergology and Clinical Immunology (2020)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (45)

Gholamreza Hassanpour (7)

Style	Citing Format
MLA	Bagheri Y, et al.. "B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency." Allergy# Asthma and Clinical Immunology, vol. 19, no. 1, 2023, pp. -.
APA	Bagheri Y, Moeini Shad T, Namazi S, Tofighi Zavareh F, Azizi G, Salami F, Sadani S, Hosseini A, Saeidi M, Pashangzadeh S, Delavari S, Mirminachi B, Rezaei N, Abolhassani H, Aghamohammadi A, Yazdani R (2023). B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency. Allergy# Asthma and Clinical Immunology, 19(1), -.
Chicago	Bagheri Y, Moeini Shad T, Namazi S, Tofighi Zavareh F, Azizi G, Salami F, Sadani S, et al.. "B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency." Allergy# Asthma and Clinical Immunology 19, no. 1 (2023): -.
Harvard	Bagheri Y et al. (2023) 'B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency', Allergy# Asthma and Clinical Immunology, 19(1), pp. -.
Vancouver	Bagheri Y, Moeini Shad T, Namazi S, Tofighi Zavareh F, Azizi G, Salami F, et al.. B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency. Allergy# Asthma and Clinical Immunology. 2023;19(1):-.
BibTex	@article{ author = {Bagheri Y and Moeini Shad T and Namazi S and Tofighi Zavareh F and Azizi G and Salami F and Sadani S and Hosseini A and Saeidi M and Pashangzadeh S and Delavari S and Mirminachi B and Rezaei N and Abolhassani H and Aghamohammadi A and Yazdani R}, title = {B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency}, journal = {Allergy# Asthma and Clinical Immunology}, volume = {19}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Bagheri Y AU - Moeini Shad T AU - Namazi S AU - Tofighi Zavareh F AU - Azizi G AU - Salami F AU - Sadani S AU - Hosseini A AU - Saeidi M AU - Pashangzadeh S AU - Delavari S AU - Mirminachi B AU - Rezaei N AU - Abolhassani H AU - Aghamohammadi A AU - Yazdani R TI - B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency JO - Allergy# Asthma and Clinical Immunology VL - 19 IS - 1 SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract