The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency

The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency Publisher Pubmed

Bagheri Y^{1, 2, 3} ; Sanaei R^{4, 5} ; Yazdani R² ; Shekarabi M^{3, 4} ; Falak R^{3, 4} ; Mohammadi J⁶ ; Abolhassani H^{2, 7} ; Aghamohammadi A²

Show Affiliations

1. Clinical Research Development Unit (CRDU), 5 Azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran
2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, 62 Qarib Street, Keshavarz Blvd., Tehran, 14194, Iran
3. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
4. Immunology Research Center (IRC), Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran
5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
6. Department of Biomedical Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
7. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden

Source: International Archives of Allergy and Immunology Published:2019

Abstract

Selective immunoglobulin A deficiency (SIgAD) is the most prevalent type of primary immunodeficiency disorder. The phenotypic feature of SIgAD is related to a defect in B lymphocyte differentiation into plasma cell-producing immunoglobulin A (IgA). In this review, we summarize the recent advances in this regard. Genetic (including major histocompatibility complex [MHC] and non-MHC genes), immunologic (including B and T lymphocyte subsets abnormality), cytokines/chemokines and their related receptors, apoptosis and microbiota defects are reviewed. The mechanisms leading to SIgAD are most likely multifactorial and it can be speculated that several pathways controlling B cells functions or regulating epigenetic of the IGHA gene encoding constant region of IgA heavy chain and long-term survival of IgA switched memory B cells and plasma cells may be defective in different SIgAD patients. © 2019 S. Karger AG, Basel.

Related Docs

View other Related Docs

1. Monogenic Mutations Associated With Iga Deficiency, Expert Review of Clinical Immunology (2016)

2. Clinical Phenotype Classification for Selective Immunoglobulin a Deficiency, Expert Review of Clinical Immunology (2015)

3. Selective Iga Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management, Scandinavian Journal of Immunology (2017)

4. Role of Apoptosis in Common Variable Immunodeficiency and Selective Immunoglobulin a Deficiency, Molecular Immunology (2016)

5. Evaluation of Effective Factors on Il-10 Signaling in B Cells in Patients With Selective Iga Deficiency, European Cytokine Network (2021)

6. B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency, Allergy# Asthma and Clinical Immunology (2023)

7. Autoimmunity in Patients With Selective Iga Deficiency, Journal of Investigational Allergology and Clinical Immunology (2015)

8. Known and Potential Molecules Associated With Altered B Cell Development Leading to Predominantly Antibody Deficiencies, Pediatric Allergy and Immunology (2021)

Experts (# of related papers)

View all Related Experts

Nima Rezaei (38)

Laleh Sharifi (7)

Style	Citing Format
MLA	Bagheri Y, et al.. "The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency." International Archives of Allergy and Immunology, vol. 179, no. 3, 2019, pp. 231-245.
APA	Bagheri Y, Sanaei R, Yazdani R, Shekarabi M, Falak R, Mohammadi J, Abolhassani H, Aghamohammadi A (2019). The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency. International Archives of Allergy and Immunology, 179(3), 231-245.
Chicago	Bagheri Y, Sanaei R, Yazdani R, Shekarabi M, Falak R, Mohammadi J, Abolhassani H, Aghamohammadi A. "The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency." International Archives of Allergy and Immunology 179, no. 3 (2019): 231-245.
Harvard	Bagheri Y et al. (2019) 'The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency', International Archives of Allergy and Immunology, 179(3), pp. 231-245.
Vancouver	Bagheri Y, Sanaei R, Yazdani R, Shekarabi M, Falak R, Mohammadi J, et al.. The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency. International Archives of Allergy and Immunology. 2019;179(3):231-245.
BibTex	@article{ author = {Bagheri Y and Sanaei R and Yazdani R and Shekarabi M and Falak R and Mohammadi J and Abolhassani H and Aghamohammadi A}, title = {The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency}, journal = {International Archives of Allergy and Immunology}, volume = {179}, number = {3}, pages = {231-245}, year = {2019} }
RIS	TY - JOUR AU - Bagheri Y AU - Sanaei R AU - Yazdani R AU - Shekarabi M AU - Falak R AU - Mohammadi J AU - Abolhassani H AU - Aghamohammadi A TI - The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency JO - International Archives of Allergy and Immunology VL - 179 IS - 3 SP - 231 EP - 245 PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract