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Thyroid Function Post-Bariatric Surgery: An Updated Systematic Review and Meta-Analysis Publisher Pubmed



Seighali N ; Khodayari Javazm A ; Kazemian S ; Matin M ; Soltani H ; Beikmohammdi M ; Mehrpour A ; Bakhtiyari M
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Source: Obesity Surgery Published:2025


Abstract

This systematic review and meta-analysis aim to comprehensively assess the effect of bariatric surgery on thyroid function. A search of PubMed, Web of Science, and Scopus databases was performed until 19 November 2024. Sixty-seven studies with 8,754 total patients included in our analysis showed a significant decrease in pooled standard mean differences (SMD) of serum TSH, total T3, and free T3 levels post operation (p-value < 0.05). Our analysis showed a significant marginal decrease in total T4 level by subgroup analysis in overall region and surgery (p-value < 0.05) whereas free T4 didn’t change significantly (p-value > 0.05). Subgroup analyses, meta-regression, and publication bias analysis were done. Based on this meta-analysis, significant reduction of TSH, marginally total T4, Total T3, and free T3 levels, as well as non-significant change of FT4 are expected following bariatric surgery. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
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