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The Primary Outcomes and Epidemiological and Clinical Features of Coronavirus Disease 2019 (Covid-19) in Iran Publisher Pubmed



Vahedianazimi A1 ; Ashtari S2 ; Alishiri G3 ; Shahriary A3 ; Saberi M4 ; Rahimibashar F5 ; Panahi Y6 ; Samadinia H7 ; Ferdosi M8 ; Jafari I1 ; Vahedi E3 ; Ghazvini A3 ; Nikpouraghdam M9 ; Goharimoghadam K10 Show All Authors
Authors
  1. Vahedianazimi A1
  2. Ashtari S2
  3. Alishiri G3
  4. Shahriary A3
  5. Saberi M4
  6. Rahimibashar F5
  7. Panahi Y6
  8. Samadinia H7
  9. Ferdosi M8
  10. Jafari I1
  11. Vahedi E3
  12. Ghazvini A3
  13. Nikpouraghdam M9
  14. Goharimoghadam K10
  15. Izadi M11
  16. Jonaidijafari N11
  17. Shojaee S12
  18. Aghdaei HA2
  19. Pourhoseingholi MA12
  20. Sahebkar A13, 14, 15, 16
Show Affiliations
Authors Affiliations
  1. 1. Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran
  2. 2. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical sciences, Tehran, Iran
  4. 4. Medicine, Quran and Hadith Research Center & Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Anesthesia and Critical Care Department, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
  7. 7. Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  8. 8. Students’ Research Committee, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran
  9. 9. Nephrology and Urology Research Center, Baqiyatallah University of Medical sciences, Tehran, Iran
  10. 10. Internal Medicine, Shariati hospital, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  12. 12. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, ShahidBeheshti University of Medical Sciences, Tehran, Iran
  13. 13. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  14. 14. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  15. 15. Halal Research Center of IRI, FDA, Tehran, Iran
  16. 16. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, Poland

Source: Advances in Experimental Medicine and Biology Published:2021


Abstract

Aim: We aimed to describe the epidemiological and clinical characteristics of Iranian patients with COVID-19. Methods: In this single-center and retrospective study, patients with confirmed COVID-19 infections were enrolled. Univariate and multivariate logistic regression methods were used to explore the risk factors associated with outcomes. Results: Of 179 patients with confirmed COVID-19 infection, 12 remained hospitalized at the end of the study and 167 were included in the final analysis. Of these, 153 (91.6%) were discharged and 14 (8.38%) died in hospital. Approximately half (50.9%) of patients suffered from a comorbidity, with diabetes or coronary heart disease being the most common in 20 patients. The most common symptoms on admission were fever, dyspnea, and cough. The mean durations from first symptoms to hospital admission was 8.64 ± 4.14 days, whereas the mean hospitalization time to discharge or death was 5.19 ± 2.42 and 4.35 ± 2.70 days, respectively. There was a significantly higher age in non-survivor patients compared with survivor patients. Multivariate regression showed increasing odds ratio (OR) of in-hospital death associated with respiratory rates >20 breaths/min (OR: 5.14, 95% CI: 1.19–22.15, p = 0.028) and blood urea nitrogen (BUN) >19 mg/dL (OR: 4.54, 95% CI: 1.30–15.85, p = 0.017) on admission. In addition, higher respiratory rate was associated with continuous fever (OR: 4.08, 95% CI: 1.18–14.08, p = 0.026) and other clinical symptoms (OR: 3.52, 95% CI: 1.05–11.87, p = 0.04). Conclusion: The potential risk factors including high respiratory rate and BUN levels could help to identify COVID-19 patients with poor prognosis at an early stage in the Iranian population. © 2021, The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.
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