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The Exo-Microrna (Mirna) Signaling Pathways in Pathogenesis and Treatment of Stroke Diseases: Emphasize on Mesenchymal Stem Cells (Mscs) Publisher Pubmed



Farahmand Y1 ; Nabiuni M2 ; Vafaei Mastanabad M3 ; Sheibani M4 ; Mahmood BS5 ; Obayes AM6 ; Asadi F7, 8 ; Davallou R9
Authors
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Authors Affiliations
  1. 1. School of Medicine, Terhan University of Medical Sciences, Tehran, Iran
  2. 2. Neurosurgery Department, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Neurosurgery Department, Faculty of Medicine, Qazvin University of Medical Science, Qazvin, Iran
  4. 4. Division of Pediatric Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States
  5. 5. Department of Anesthesia Techniques, Al-Noor University College, Nineveh, Iraq
  6. 6. College of Nursing, National University of Science and Technology, Dhi Qar, Iraq
  7. 7. Department of Genetics, Fars Science and Research Branch, Islamic Azad University, Marvdasht, Iran
  8. 8. Department of Genetics, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
  9. 9. Department of Neurology, Sayyad Shirazi Hospital, Golestan University of Medical Siences, Gorgan, Iran

Source: Cell Biochemistry and Function Published:2024


Abstract

A major factor in long-term impairment is stroke. Patients with persistent stroke and severe functional disabilities have few therapy choices. Long noncoding RNAs (lncRNAs) may contribute to the regulation of the pathophysiologic processes of ischemic stroke as shown by altered expression of lncRNAs and microRNA (miRNAs) in blood samples of acute ischemic stroke patients. On the other hand, multipotent mesenchymal stem cells (MSCs) increase neurogenesis, and angiogenesis, dampen neuroinflammation, and boost brain plasticity to improve functional recovery in experimental stroke models. MSCs can be procured from various sources such as the bone marrow, adipose tissue, and peripheral blood. Under the proper circumstances, MSCs can differentiate into a variety of mature cells, including neurons, astrocytes, and oligodendrocytes. Accordingly, the capability of MSCs to exert neuroprotection and also neurogenesis has recently attracted more attention. Nowadays, lncRNAs and miRNAs derived from MSCs have opened new avenues to alleviate stroke symptoms. Accordingly, in this review article, we examined various studies concerning the lncRNAs and miRNAs' role in stroke pathogenesis and delivered an overview of the therapeutic role of MSC-derived miRNAs and lncRNAs in stroke conditions. © 2024 John Wiley & Sons Ltd.
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