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Paracrine Effects of Mesenchymal Stem Cells in Ischemic Stroke: Opportunities and Challenges Publisher Pubmed



Asgari Taei A1 ; Khodabakhsh P1 ; Nasoohi S1 ; Farahmandfar M2 ; Dargahi L3
Authors
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Authors Affiliations
  1. 1. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Molecular Neurobiology Published:2022


Abstract

It is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells (MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander effects rather than to cell replacement in infarcted areas. This therapeutic plasticity is due to MSCs’ ability to secrete a broad range of bioactive molecules including growth factors, trophic factors, cytokines, chemokines, and extracellular vesicles, overall known as the secretome. The secretome derivatives, such as conditioned medium (CM) or purified extracellular vesicles (EVs), exert remarkable advantages over MSC transplantation in stroke treating. Here, in this review, we used published information to provide an overview on the secretome composition of MSCs, underlying mechanisms of therapeutic effects of MSCs, and preclinical studies on MSC-derived products application in stroke. Furthermore, we discussed current advantages and challenges for successful bench-to-bedside translation. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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