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An Updated Review of Various Medicinal Applications of P-Coumaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation Publisher Pubmed



Abazari MF1 ; Nasiri N2 ; Karizi SZ3 ; Nejati F2 ; Haghiaminjan H4 ; Norouzi S5 ; Piri P3 ; Estakhr L6 ; Faradonbeh DR7 ; Kohandani M8 ; Daliri K9, 10 ; Sanadgol N11, 12 ; Askari H13
Authors
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Authors Affiliations
  1. 1. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Institute of Molecular Biology, Vrije University Brussels, Brussels, Belgium
  3. 3. Department of Biology, Varamin Pishva Branch, Islamic Azad University, Pishva, Varamin, Iran
  4. 4. Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  5. 5. Department of Biology, Faculty of Science and Research, Islamic Azad University, Tehran, Iran
  6. 6. Faculty of Dentistry, Gilan University of Medical sciences, Gilan, Iran
  7. 7. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Biology, Faculty of Biological Sciences, Islamic Azad University, East Tehran Branch, Tehran, Iran
  9. 9. Child Developmental Center, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Dehkade Salamat (Kajed), Biomedical Center, Faroogh, Iran
  11. 11. Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran
  12. 12. Department of Biomolecular Sciences, School of Pharmaceutical Sciences, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
  13. 13. Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Mini-Reviews in Medicinal Chemistry Published:2021


Abstract

P-Coumaric acid (p-CA) is a hydroxycinnamic acid, an organic compound that is a hydroxyl derivative of cinnamic acid. P-CA is the most abundant isomer in nature and can be found in a wide variety of edible plants such as fungi, peanuts, navy beans, tomatoes, carrots, basil, and garlic. Recently, the therapeutic properties of p-CA have received a great deal of attention from scientific society. Here, we described the medicinal effects of p-CA on various pathological conditions. This review was performed via evaluating PubMed reported studies from January 2010 to January 2020. Also, reference lists were checked to find additional studies. All intermediation or complementarity of animal models, case-control and cohort studies, in vitro studies, and controlled trials (CTs) on p-CA were acceptable. However plant extract studies without indication of main active substances were excluded due to the considerable diversities and heterogeneities. According to recent evidence regarding the beneficial effects of p-CA, numerous diseases such as nephropathies, cardiovascular diseases, neuroinflammatory diseases, liver diseases, cancers, and some metabolic disorders could potentially be controlled by this natural herb. Interestingly, autophagy is a novel molecular mechanism involved in the crosstalk between classic effects of p-CA and introduces alternative therapeutic pathways for this compound. Much work remains in clarifying the main therapeutic properties among the various p-CA effects; these will be the subject of forthcoming work, resulting in presenting further mechanism of action. © 2021 Bentham Science Publishers.
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