Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synthesis and Characterisation of Highly Interconnected Porous Poly(Ε-Caprolactone)-Collagen Scaffolds: A Therapeutic Design to Facilitate Tendon Regeneration Publisher



Mozafari M1 ; Kargozar S2 ; De Santiago GT3, 4, 5 ; Mohammadi MR6 ; Milan PB7, 8 ; Foroutan Koudehi M9 ; Aghabarari B10 ; Nourani MR9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Bioengineering Research Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center (MERC), Tehran, Iran
  2. 2. Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Biomaterials Innovation Research Center, Brigham and Women’s Hospital, Harvard Medical School, MA, United States
  4. 4. Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology and Microsystems Technologies Laboratories, Massachusetts Institute of Technology, Cambridge, MA, United States
  5. 5. Centro de Biotecnologia-FEMSA, Tecnologico de Monterrey at Monterrey, Monterrey, Mexico
  6. 6. Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA, United States
  7. 7. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Faculty of Advanced Technologies in Medicine, Department of Tissue Engineering & Regenerative Medicine, Iran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Tissue Engineering and Regenerative Medicine, Nano Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  10. 10. Nanomaterials Group, Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center (MERC), Tehran, Iran

Source: Materials Technology Published:2018


Abstract

Current tissue-engineering approaches require improved biomaterials to balance microstructural and mechanical design criteria. We investigated the effect of adding a naturally occurring polymer, collagen, to a synthetic scaffold made of poly(ε-caprolactone) (PCL). Hybrid PCL-collagen scaffolds with different collagen concentrations were prepared by solvent casting and freeze-drying techniques that included a subsequent chemical cross-linking. Scanning electron microscopy and Fourier transform infrared spectroscopy were used to characterise the microstructure and chemical interactions of the scaffolds. We found that the porous structure of the scaffolds can be tailored by changing the collagen concentration. In addition, we concluded that the scaffolds with 40% collagen exhibit remarkable enhancement in physicochemical and biological characteristics for tendon regeneration. The regenerated tissues were oriented longitudinally in relation to the long axis of the natural tendon, with a substantial number of blood vessels appearing deep within the scaffolds. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Related Docs
View other Related Docs
1. Agarose-Based Biomaterials for Tissue Engineering, Carbohydrate Polymers (2018)
2. A Bird's Eye View on the Use of Electrospun Nanofibrous Scaffolds for Bone Tissue Engineering: Current State-Of-The-Art, Emerging Directions and Future Trends, Nanomedicine: Nanotechnology# Biology# and Medicine (2016)
3. Drug Loading and Delivery Using Nanofibers Scaffolds, Artificial Cells# Nanomedicine and Biotechnology (2017)
4. 3D–Printed Biphasic Calcium Phosphate Scaffolds Coated With an Oxygen Generating System for Enhancing Engineered Tissue Survival, Materials Science and Engineering C (2018)
5. Drug Release, Cell Adhesion and Wound Healing Evaluations of Electrospun Carboxymethyl Chitosan/Polyethylene Oxide Nanofibres Containing Phenytoin Sodium and Vitamin C, IET Nanobiotechnology (2015)
6. Bone Regeneration in Rat Using a Gelatin/Bioactive Glass Nanocomposite Scaffold Along With Endothelial Cells (Huvecs), International Journal of Applied Ceramic Technology (2018)
7. Patterning the Surface Roughness of a Nano Fibrous Scaffold for Transdermal Drug Release, International Journal of Nano Dimension (2019)
8. When Size Matters: Biological Response to Strontium- and Cobalt-Substituted Bioactive Glass Particles, Materials Today: Proceedings (2018)
Experts (# of related papers)
View all Related Experts
Nasrin Lotfibakhshaiesh (2)
Mahmoud Azami (1)
Other Related Docs
9. A Facile Route to the Synthesis of Anilinic Electroactive Colloidal Hydrogels for Neural Tissue Engineering Applications, Journal of Colloid and Interface Science (2018)
10. Nanoengineered Biomaterials for Diaphragm Regeneration, Nanoengineered Biomaterials for Regenerative Medicine (2018)
11. Acceleration of Bone Regeneration in Bioactive Glass/Gelatin Composite Scaffolds Seeded With Bone Marrow-Derived Mesenchymal Stem Cells Over-Expressing Bone Morphogenetic Protein-7, Materials Science and Engineering C (2017)
12. Membranes for Controlled Release, Drug Delivery Systems (2017)
13. Metformin-Loaded Pcl/Pva Fibrous Scaffold Preseeded With Human Endometrial Stem Cells for Effective Guided Bone Regeneration Membranes, ACS Biomaterials Science and Engineering (2021)
14. Chitosan/Polyvinyl Alcohol Nanofibrous Membranes: Towards Green Super-Adsorbents for Toxic Gases, Heliyon (2019)
15. Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering, Materials (2017)
16. Mesoporous Bioactive Glasses: Promising Platforms for Antibacterial Strategies, Acta Biomaterialia (2018)
17. Animal- and Human-Based Evidence for the Protective Effects of Stem Cell Therapy Against Cardiovascular Disorders, Journal of Cellular Physiology (2019)
18. Bioactive Glasses: Sprouting Angiogenesis in Tissue Engineering, Trends in Biotechnology (2018)
19. Evaluation of the Effective Electrospinning Parameters Controlling Kefiran Nanofibers Diameter Using Modelling Artificial Neural Networks, Nanomedicine Research Journal (2017)
20. Synergistic Combination of Bioactive Glasses and Polymers for Enhanced Bone Tissue Regeneration, Materials Today: Proceedings (2018)
21. Developed Methods for the Preparation of Electrospun Nanofibers Containing Plant-Derived Oil or Essential Oil: A Systematic Review, Polymer Bulletin (2020)
22. Dextran Hydrogels Incorporated With Bioactive Glass-Ceramic: Nanocomposite Scaffolds for Bone Tissue Engineering, Carbohydrate Polymers (2018)
23. Osteogenic Potential of Stem Cells-Seeded Bioactive Nanocomposite Scaffolds: A Comparative Study Between Human Mesenchymal Stem Cells Derived From Bone, Umbilical Cord Wharton's Jelly, and Adipose Tissue, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2018)
24. Bioactive Glasses Entering the Mainstream, Drug Discovery Today (2018)
25. Bone Tissue Engineering Using Human Cells: A Comprehensive Review on Recent Trends, Current Prospects, and Recommendations, Applied Sciences (Switzerland) (2019)
26. Dexamethasone Loaded Multi-Layer Poly-L-Lactic Acid/Pluronic P123 Composite Electrospun Nanofiber Scaffolds for Bone Tissue Engineering and Drug Delivery, Pharmaceutical Development and Technology (2019)
27. Strontium- and Cobalt-Substituted Bioactive Glasses Seeded With Human Umbilical Cord Perivascular Cells to Promote Bone Regeneration Via Enhanced Osteogenic and Angiogenic Activities, Acta Biomaterialia (2017)
28. Development of Polyvinyl Alcohol Fibrous Biodegradable Scaffolds for Nerve Tissue Engineering Applications: In Vitro Study, International Journal of Polymeric Materials and Polymeric Biomaterials (2015)
29. Protein Adsorption on Polymers, Materials Today Communications (2018)
30. Poloxamer: A Versatile Tri-Block Copolymer for Biomedical Applications, Acta Biomaterialia (2020)
31. Bioactive Glasses: Where Are We and Where Are We Going?, Journal of Functional Biomaterials (2018)