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A Bird's Eye View on the Use of Electrospun Nanofibrous Scaffolds for Bone Tissue Engineering: Current State-Of-The-Art, Emerging Directions and Future Trends Publisher Pubmed



Rezvani Z1 ; Venugopal JR2 ; Urbanska AM3 ; Mills DK4 ; Ramakrishna S2, 5 ; Mozafari M1, 6, 7
Authors
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Authors Affiliations
  1. 1. Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), Tehran, Iran
  2. 2. Center for Nanofibers and Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore
  3. 3. Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, United States
  4. 4. School of Biological Sciences and the Center for Biomedical Engineering and Rehabilitation Science, Louisiana Tech University, Ruston, LA, United States
  5. 5. Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, China
  6. 6. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine: Nanotechnology# Biology# and Medicine Published:2016


Abstract

Tissue engineering aims to develop therapeutic products that utilize a combination of scaffolds with viable cell systems or responsive biomolecules derived from such cells, for the repair, restoration/regeneration of tissues. Here, the main goal is to enable the body to heal itself by the introduction of electrospun scaffolds, such that the body recognizes them as its own and in turn uses them to regenerate neo-native functional tissues. During the last decade, innovative nanofibrous scaffolds have attracted substantial interest in bone tissue engineering. The electrospinning process makes it possible to fabricate appropriate scaffolds for bone tissue engineering from different categories of nanobiomaterials having the ability of controlled delivery of drugs in the defective tissues. It is expected that with the progress in science and technology, better bone constructs will be proposed in the future. This review discusses the innovative approaches into electrospinning techniques for the fabrication of nanofibrous scaffolds for bone tissue engineering. © 2016 Elsevier Inc.
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