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Association of Vitamin D Status With Metabolic Syndrome and Its Components: A Cross-Sectional Study in a Population of High Educated Iranian Adults Publisher Pubmed



Mansouri M1 ; Abasi R2 ; Nasiri M3 ; Sharifi F4 ; Vesaly S1 ; Sadeghi O5 ; Rahimi N1 ; Sharif NA1
Authors
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Authors Affiliations
  1. 1. Student Health Services, Health Center of Tarbiat Modares University, Tehran, Iran
  2. 2. Research Center for Prevention of Cardiovascular Disease, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Operating Room Technology, School of Paramedicine, Qom University of Medical Sciences, Qom, Iran
  4. 4. Elderly Health Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2018


Abstract

Aim: We aimed to assess the association of vitamin D status with metabolic syndrome and its components among high educated Iranian adults. Method: In this cross-sectional study, 352 faculty members with age of 35 years or more, belong to Tarbiat Modares University, Tehran, Islamic Republic of Iran, were recruited during 2016 and 2017. Fasting blood samples were obtained to quantify serum 25(OH)D concentrations, glycemic indicators and lipid profile. Metabolic syndrome was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III). Multivariate logistic regression adjusted for potential confounders was used to evaluate the association between vitamin D status and metabolic syndrome. Result: Metabolic syndrome and vitamin D insufficiency were prevalent among 26% and 60.2% of subjects, respectively. There was no statistically significant difference in the prevalence of metabolic syndrome across quartiles of 25(OH)D levels either before or after adjusting for potential confounders (OR: 0.94, 95% CI: 0.43–1.95). In terms of metabolic syndrome components, subjects in the highest quartile of vitamin D levels had 59% decreased risk of abdominal obesity compared with those in the lowest quartile (OR: 0.41, 95% CI: 0.17–0.99), after adjusting for potential confounders. Such inverse relationship was also seen for elevated blood pressure (OR: 0.37, 95% CI: 0.14–0.99), and abnormal glucose homeostasis (OR: 0.40, 95% CI: 0.19–0.85). Conclusion: Serum levels of 25(OH)D was inversely associated with the risk of abdominal obesity, hypertension, and abnormal glucose homeostasis. However, no significant relationship was seen for metabolic syndrome. © 2018
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