Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial

Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial Publisher Pubmed

Ebadi SA¹ ; Sharifi L² ; Rashidi E¹ ; Ebadi SS³ ; Khalili S¹ ; Sadeghi S¹ ; Afzali N⁴ ; Shiri SM⁵

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1. Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Uro-Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran

Source: Obesity Research and Clinical Practice Published:2021

Abstract

Introduction: Hypovitaminosis D which is a frequent problem in overweight and obese individuals, seems to interfere with cells responsible for control of glycemic status. Therefore, the current research intended to study the impact of supplementation with vitamin D on insulin homeostasis among healthy obese and overweight individuals. Methods: The current study was conducted among obese or overweight individuals who had hypovitaminosis D. After separation of participants into two groups, one group received vitamin D pearls (50,000 IU/weekly) for eight weeks, whereas another group received a placebo over the same period. Next, the level of vitamin D, fasting blood sugar (FBS), fasting insulin, Homeostasis Model Assessment 2 for Insulin Resistance (HOMA2-IR), Function of β-cell (HOMA2-β), and Insulin Sensitivity (HOMA2-S) and lipid profile of participants were evaluated. Results: Overall, 67.2% of the participants were female. No considerable difference was observed concerning biochemical parameters among the study groups at baseline. After eight weeks, the mean (SD) level of vitamin D was significantly lower in the placebo group than those in the vitamin D group. (38.6 ± 8.1 vs. 14.9 ± 6.4; P < 0.001). The patients who received vitamin D had significant lower levels of FBS (P < 0.001), fasting insulin (P < 0.001), HOMA2-IR (P < 0.001), and HOMA2-β (P = 0.03), than the placebo group. The HOMA2-S was significantly enhanced in vitamin D group, while it reduced in another group (P < 0.001). However, no considerable decrease was found in triglyceride, cholesterol, high-density lipoprotein or low-density lipoprotein. Conclusion: Supplementation with vitamin D improved sensitivity to insulin and pancreatic function of β cells of healthy overweight and obese adults. © 2021 Asia Oceania Association for the Study of Obesity

2. The Interactive Effect of Vitamin D3 Supplementation and Vitamin D Receptor Polymorphisms on Weight and Body Composition in Overweight Women With Hypovitaminosis D: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Canadian Journal of Physiology and Pharmacology (2022)

3. Effectiveness of Vitamin D Therapy in Improving Metabolomic Biomarkers in Obesity Phenotypes: Two Randomized Clinical Trials, International Journal of Obesity (2018)

4. The Joint Association of Serum Vitamin D Status and Cardiorespiratory Fitness With Obesity and Metabolic Syndrome in Tehranian Adults, British Journal of Nutrition (2022)

5. Air Pollution, Environmental Chemicals, and Smoking May Trigger Vitamin D Deficiency: Evidence and Potential Mechanisms, Environment International (2019)

6. Circulating Vitamin D and the Risk of Gestational Diabetes: A Systematic Review and Dose-Response Meta-Analysis, Endocrine (2020)

7. Vitamin D Status and Systemic Redox Biomarkers in Adults With Obesity, Clinical Nutrition ESPEN (2021)

8. Role of Vitamin D in Pathogenesis and Severity of Covid-19 Infection, Archives of Physiology and Biochemistry (2023)

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Style	Citing Format
MLA	Ebadi SA, et al.. "Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial." Obesity Research and Clinical Practice, vol. 15, no. 3, 2021, pp. 256-261.
APA	Ebadi SA, Sharifi L, Rashidi E, Ebadi SS, Khalili S, Sadeghi S, Afzali N, Shiri SM (2021). Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial. Obesity Research and Clinical Practice, 15(3), 256-261.
Chicago	Ebadi SA, Sharifi L, Rashidi E, Ebadi SS, Khalili S, Sadeghi S, Afzali N, Shiri SM. "Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial." Obesity Research and Clinical Practice 15, no. 3 (2021): 256-261.
Harvard	Ebadi SA et al. (2021) 'Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial', Obesity Research and Clinical Practice, 15(3), pp. 256-261.
Vancouver	Ebadi SA, Sharifi L, Rashidi E, Ebadi SS, Khalili S, Sadeghi S, et al.. Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial. Obesity Research and Clinical Practice. 2021;15(3):256-261.
BibTex	@article{ author = {Ebadi SA and Sharifi L and Rashidi E and Ebadi SS and Khalili S and Sadeghi S and Afzali N and Shiri SM}, title = {Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial}, journal = {Obesity Research and Clinical Practice}, volume = {15}, number = {3}, pages = {256-261}, year = {2021} }
RIS	TY - JOUR AU - Ebadi SA AU - Sharifi L AU - Rashidi E AU - Ebadi SS AU - Khalili S AU - Sadeghi S AU - Afzali N AU - Shiri SM TI - Supplementation With Vitamin D and Insulin Homeostasis in Healthy Overweight and Obese Adults: A Randomized Clinical Trial JO - Obesity Research and Clinical Practice VL - 15 IS - 3 SP - 256 EP - 261 PY - 2021 ER -

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