The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population

The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population Publisher

Alaeishahmiri F¹ ; Khamseh ME¹ ; Manhoei K² ; Yadegari H² ; Kazemi H² ; Meshkini M³

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1. Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), No. 10, Firouzeh St, Vali-asr St, Vali-asr Sq, Tehran, Iran
2. SAIPA Corporation, Tehran, Iran
3. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences (IUMS), Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2020

Abstract

Background: Vitamin D deficiency may accelerate the risk of type 2 diabetes mellitus. The association of vitamin D with hyperglycemia may be influenced by lifestyle. Objective: To evaluate the relationship between vitamin D status and hyperglycemia among the workers’ population. Methods: This was a medical records review of 7054 Iranian factory workers participating in an annual health check-up for employees. Of those, potential participants were included in this analysis if data for serum 25-hydroxyvitamin D [25(OH) D] levels were also available. Results: Data of 429 male participants were used for this analysis. Of those, 61.07% had serum 25(OH)D concentrations lower than the sufficient level [≥20 ng/ml]. Hyperglycemic participants had significantly lower 25(OH)D than those with normal fasting blood glucose (FBG). Regression analyses highlighted serum 25(OH)D as a significant determinant of hyperglycemia [OR: 0.943(0.901, 988); p = 0.01]. The association between 25(OH)D and FBG remained significant after adjustment for potential confounders (p = 0.008). Using the ROC analysis, the serum 25(OH)D value of 14.7 ng/ml was the optimal cut-off point to predict hyperglycemia in this population (sensitivity: 63.6%, specificity: 62.3%, p = 0.01). Conclusion: Our results revealed a considerable proportion of participants with serum 25(OH)D below the optimal level as well as a significant inverse association between vitamin D status and hyperglycemia among the factory workers. These findings highlight the importance of including the evaluation of vitamin D status as a part of annual health examinations for employees, and may help health policy- makers prevent or delay type 2 diabetes mellitus among the workers’ population. © 2019, Springer Nature Switzerland AG.

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Style	Citing Format
MLA	Alaeishahmiri F, et al.. "The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population." Journal of Diabetes and Metabolic Disorders, vol. 19, no. 1, 2020, pp. 5-12.
APA	Alaeishahmiri F, Khamseh ME, Manhoei K, Yadegari H, Kazemi H, Meshkini M (2020). The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population. Journal of Diabetes and Metabolic Disorders, 19(1), 5-12.
Chicago	Alaeishahmiri F, Khamseh ME, Manhoei K, Yadegari H, Kazemi H, Meshkini M. "The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population." Journal of Diabetes and Metabolic Disorders 19, no. 1 (2020): 5-12.
Harvard	Alaeishahmiri F et al. (2020) 'The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population', Journal of Diabetes and Metabolic Disorders, 19(1), pp. 5-12.
Vancouver	Alaeishahmiri F, Khamseh ME, Manhoei K, Yadegari H, Kazemi H, Meshkini M. The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population. Journal of Diabetes and Metabolic Disorders. 2020;19(1):5-12.
BibTex	@article{ author = {Alaeishahmiri F and Khamseh ME and Manhoei K and Yadegari H and Kazemi H and Meshkini M}, title = {The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population}, journal = {Journal of Diabetes and Metabolic Disorders}, volume = {19}, number = {1}, pages = {5-12}, year = {2020} }
RIS	TY - JOUR AU - Alaeishahmiri F AU - Khamseh ME AU - Manhoei K AU - Yadegari H AU - Kazemi H AU - Meshkini M TI - The Optimal Vitamin D Cut-Off Value Associated With Hyperglycemia in an Iranian Population JO - Journal of Diabetes and Metabolic Disorders VL - 19 IS - 1 SP - 5 EP - 12 PY - 2020 ER -

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