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Immunoengineering in Glioblastoma Imaging and Therapy Publisher Pubmed



Zanganeh S1 ; Georgala P1 ; Corbo C2 ; Arabi L3 ; Ho JQ4 ; Javdani N5 ; Sepand MR6 ; Cruickshank K1 ; Campesato LF1 ; Weng CH1 ; Hemayat S6 ; Andreou C7 ; Alvim R1 ; Hutter G2 Show All Authors
Authors
  1. Zanganeh S1
  2. Georgala P1
  3. Corbo C2
  4. Arabi L3
  5. Ho JQ4
  6. Javdani N5
  7. Sepand MR6
  8. Cruickshank K1
  9. Campesato LF1
  10. Weng CH1
  11. Hemayat S6
  12. Andreou C7
  13. Alvim R1
  14. Hutter G2
  15. Rafat M8, 9, 10
  16. Mahmoudi M11
Show Affiliations
Authors Affiliations
  1. 1. Sloan Kettering Institute for Cancer Research, New York, NY, United States
  2. 2. School of Medicine and Surgery, Nanomedicine Center NANOMIB, University of Milano-Bicocca, Milan, Italy
  3. 3. Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. Albert Einstein College of Medicine, Bronx, NY, United States
  5. 5. Institute De Recherche Clinique De Montreal, Montreal, QC, Canada
  6. 6. Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Electrical and Computer Engineering, University of Cyprus, Nicosia, Cyprus
  8. 8. Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, United States
  9. 9. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States
  10. 10. Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, United States
  11. 11. Precision Health Program, Michigan State University, East Lansing, MI, United States

Source: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology Published:2019


Abstract

Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood–brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy and nanotechnology have demonstrated potential in addressing these obstacles by enabling precise targeting of brain tumors to minimize adverse effects, while increasing targeted drug delivery across the BBB. In addition to treating the tumors, these approaches may be used in conjunction with imaging modalities, such as magnetic resonance imaging and positron emission tomography to enhance the prognosis procedures. This review aims to provide mechanistic understanding of immune system regulation in the central nervous system and the benefits of nanoparticles in the prognosis of brain tumors. This article is characterized under:. Diagnostic Tools ' in vivo Nanodiagnostics and Imaging. Nanotechnology Approaches to Biology ' Cells at the Nanoscale. Nanotechnology Approaches to Biology ' Nanoscale Systems in Biology. © 2019 Wiley Periodicals, Inc.
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