Exposure to Ascaris Lumbricoides Infection and Risk of Childhood Asthma in North of Iran Publisher Pubmed



Mohammadzadeh I¹ ; Rostami A² ; Darvish S² ; Mehravar S³ ; Pournasrollah M¹ ; Javanian M² ; Esmaeili Dooki M¹ ; Gamble HR⁴ Show Affiliations
Source: Infection Published:2019

Abstract

Background: Asthma and Ascaris lumbricoides infection are common health issues affecting 250 and 700 million people worldwide, respectively. The relationship between ascariasis and asthma is a matter of substantial interest and research. Methods: We performed a case–control study to evaluate whether the exposure to Ascaris infection is associated with asthma in children. We also assessed potential risk factors for Ascaris infection and asthma in study area. We enrolled 145 asthmatic children and 115 healthy controls. The Global Initiative for Asthma guideline was used to evaluate asthma symptoms and severity in study participants. Ascaris infection was assessed by the presence of anti-Ascaris IgG ≥ 11 IU/mL measured by enzyme-linked immunosorbent assay. Results: We have found a significant relationship between exposure to Ascaris and asthma (odds ratio, 2.92; 95% CI 1.04–8.18; P value = 0.034), and this relationship remained significant after adjustment for covariates (adjusted OR, 3.36; 95% CI 1.04–13%; P value = 0.047). Ascaris infection was more frequent in children with mild sustainable asthma (13.2%; 15/113) than in children with moderate sustainable asthma (6.2%, 2/32), although there was a non-significant difference between these groups (OR, 2.3; 95% CI 0.5–10.1; P value = 0.35). Based on results of a multi-regression analysis, contact with soil (OR, 6.7; 95% CI 1.9–23.5), and drinking unsafe water (OR, 4.2; 95% CI 1.2–14.2) were significant risk factors for Ascaris infection in the study area. Conclusion: Results of this study suggest that A. lumbricoides infection might affect susceptibility to asthma in children. These results could be useful in prevention, early diagnosis and management of childhood asthma. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.