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The Prevalence of Asthma in Adult Population of Southwestern Iran and Its Association With Chronic Rhinosinusitis: A Ga2len Study Publisher



Ostovar A1 ; Fokkens WJ2 ; Pordel S3 ; Movahed A4 ; Ghasemi K5 ; Marzban M6 ; Farrokhi S3
Authors
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Authors Affiliations
  1. 1. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, Netherlands
  3. 3. Department of Immunology and Allergy, Persian Gulf Tropical Medicine Research Center, Persian Gulf Biomedical Research Institute, Bushehr University of Medical Sciences, PO Box: 75 16 68 88 76 Sangi St, Bushehr, Iran
  4. 4. Persian Gulf Tropical Research Center, Biochemistry Group, Bushehr University of Medical Sciences, Bushehr, Iran
  5. 5. Department of Pediatrics, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  6. 6. Department of Epidemiology, School of Public Health, Bushehr University of Medical Sciences, Bushehr, Iran

Source: Clinical and Translational Allergy Published:2019


Abstract

Background: Asthma is recognized as a major public health concern in the world. The aim of this investigation was to evaluate the prevalence of asthma by using the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire and examine its association with chronic rhinosinusitis, in the province of Bushehr, Southwestern of Iran. Methods: In a cross-sectional, population-based study, a total of 5420 invited individuals, aged 15-65, were selected through a multi-stage, stratified, cluster random sampling and from which 5201 completed the GA2LEN questionnaire (response rate = 95.9%). The prevalence of asthma, current, and physician-diagnosed asthma were analyzed by using sex and age groups and the association of asthma and chronic rhinosinusitis (CRS) was investigated using a multiple logistic regression model. Results: Based on the information from the GA2LEN questionnaire, the overall prevalence of asthma in the population under study was 10.0% (95% CI 9.2-10.8). Moreover, the prevalence of current asthma was 8.9% (95% CI 8.1-9.7). Further, the prevalence of current early, late-onset and physician-diagnosed asthma within the asthma group was 51.1% (95% CI 46.5-55.7), 48.9% (95% CI 44.3-53.5) and 3.9% (95% CI 2.1-2.5), respectively. Additionally, CRS was more frequent among the participants with asthma [(57.3%, OR = 2.3; 95% CI 2.1-2.5)], and there was a significant association between CRS and current, early and late-onset of asthma (P < 0.001; OR = 4.4, 3.2 and 6, respectively). Conclusion: This large population study conducted in the southwestern part of Iran suggests that the prevalence of asthma is high. Moreover, the result of this study showed a strong association of asthma with CRS; also after adjusting for sex, age, educational level, and smoking. © 2019 The Author(s).
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