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A Comprehensive Review on the Role of Non-Coding Rnas in the Pathophysiology of Bipolar Disorder Publisher Pubmed



Ghafourifard S1 ; Badrlou E1 ; Taheri M2 ; Dursteler KM3, 4 ; Bruhl AB5 ; Sadeghibahmani D5, 6, 7 ; Brand S5, 6, 8, 9
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 65167198721, Iran
  2. 2. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, 65167198721, Iran
  3. 3. Psychiatric Clinics, Division of Substance Use Disorders, University of Basel, Basel, 4002, Switzerland
  4. 4. Center for Addictive Disorders, Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, 8001, Switzerland
  5. 5. Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, Basel, 4002, Switzerland
  6. 6. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, 67146, Iran
  7. 7. Departments of Physical Therapy, University of Alabama at Birmingham, Birmingham, 35294, AL, United States
  8. 8. Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, University of Basel, Basel, 4052, Switzerland
  9. 9. School of Medicine, Tehran University of Medical Sciences, Tehran, 25529, Iran

Source: International Journal of Molecular Sciences Published:2021


Abstract

Aim: Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs). Methods: We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder. Results: Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation. Conclusion: Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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