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Lncrna Linc00261 Sponge's Mir-33-Regulated Pi3-Kinase in Autism Disorder Publisher



Rad HF1 ; Karimi MS2 ; Behfar M3 ; Nazari A4 ; Hassani N5 ; Hasanvand A6, 7 ; Farhadi A8
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Source: Gene Reports Published:2025


Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by social communication and sensory processing difficulties. Emerging evidence suggests the involvement of long non-coding RNAs (lncRNAs), particularly LIN00261, in its pathogenesis. It has been identified that LIN00261 is differentially expressed in the brains of individuals with ASD and acts as a competing endogenous RNA (ceRNA), “sponging” microRNA-33 (miR-33). This interaction could indirectly influence the PI3-kinase signaling pathway, impacting neuronal maturation and function. Manipulating LIN00261 levels in cellular models of ASD affects PI3-kinase signaling activity, suggesting a potential causal link between LIN00261 and PI3-kinase dysregulation in ASD. Furthermore, investigations have revealed associations between LIN00261 polymorphisms and ASD susceptibility. In conclusion, the lncRNA LIN00261 emerges as a promising candidate gene in ASD, potentially influencing the PI3-kinase signaling pathway through its interaction with miR-33. © 2024 Elsevier Inc.
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