In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity

In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity Publisher Pubmed

Hosseinikharat M^{1, 2} ; Zargarian D¹ ; Alizadeh AM^{2, 3} ; Karami K⁴ ; Saeidifar M⁵ ; Khalighfard S⁶ ; Dubrulle L¹ ; Zakariazadeh M⁷ ; Cloutier JP¹ ; Sohrabijam Z⁵

Show Affiliations

1. Departement de Chimie, Universite de Montreal, Montreal, H3C 3J7, QC, Canada
2. Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Breast Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran
5. Department of Nanotechnology and Advanced Materials, Materials and Energy Research Center, Karaj, Iran
6. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
7. Research Institute for Fundamental Sciences (RIFS), University of Tabriz, Tabriz, Iran

Source: Dalton Transactions Published:2018

Abstract

A family of organonickel complexes has been prepared, fully characterized, and tested for their antiproliferative activity against estrogen-responsive human breast cancer cells (MCF7). The three SCS-type pincer ligands HL1, HL2, and HL3 and their corresponding Ni(ii) complexes NiL1, NiL2, and NiL3 have been synthesized and fully characterized, including by single crystal diffraction studies for the complexes. The complexes possess square planar geometry with two symmetrical 5-membered nickellacycles. Fluorescence spectroscopy, circular dichroism measurements, molecular modeling, colorimetric based assay and tumor transplantation studies were used to evaluate the protein binding and antiproliferative activities of these organometallic complexes both in vitro and in vivo. Fluorescence quenching was used to investigate bovine serum albumin (BSA) interaction at different temperatures (293, 303 and 313 K), and the results were analyzed using the classical Stern-Volmer equation, allowing us to propose a dynamic quenching mechanism. Studies in vitro on the antiproliferative activity of the three organonickel complexes against estrogen-responsive human breast cancer cells (MCF7) showed promising antitumor activity for NiL1 containing pyrrolidine fragments. In vivo administration of this compound significantly inhibits tumor growth in estrogen-dependent MC4L2 cancer cells in female BALB/c mice. © The Royal Society of Chemistry.

Style	Citing Format
MLA	Hosseinikharat M, et al.. "In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity." Dalton Transactions, vol. 47, no. 47, 2018, pp. 16944-16957.
APA	Hosseinikharat M, Zargarian D, Alizadeh AM, Karami K, Saeidifar M, Khalighfard S, Dubrulle L, Zakariazadeh M, Cloutier JP, Sohrabijam Z (2018). In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity. Dalton Transactions, 47(47), 16944-16957.
Chicago	Hosseinikharat M, Zargarian D, Alizadeh AM, Karami K, Saeidifar M, Khalighfard S, Dubrulle L, Zakariazadeh M, Cloutier JP, Sohrabijam Z. "In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity." Dalton Transactions 47, no. 47 (2018): 16944-16957.
Harvard	Hosseinikharat M et al. (2018) 'In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity', Dalton Transactions, 47(47), pp. 16944-16957.
Vancouver	Hosseinikharat M, Zargarian D, Alizadeh AM, Karami K, Saeidifar M, Khalighfard S, et al.. In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity. Dalton Transactions. 2018;47(47):16944-16957.
BibTex	@article{ author = {Hosseinikharat M and Zargarian D and Alizadeh AM and Karami K and Saeidifar M and Khalighfard S and Dubrulle L and Zakariazadeh M and Cloutier JP and Sohrabijam Z}, title = {In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity}, journal = {Dalton Transactions}, volume = {47}, number = {47}, pages = {16944-16957}, year = {2018} }
RIS	TY - JOUR AU - Hosseinikharat M AU - Zargarian D AU - Alizadeh AM AU - Karami K AU - Saeidifar M AU - Khalighfard S AU - Dubrulle L AU - Zakariazadeh M AU - Cloutier JP AU - Sohrabijam Z TI - In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity JO - Dalton Transactions VL - 47 IS - 47 SP - 16944 EP - 16957 PY - 2018 ER -

Style

Citing Format

MLA

Hosseinikharat M, et al.. "In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity." Dalton Transactions, vol. 47, no. 47, 2018, pp. 16944-16957.

APA

Hosseinikharat M, Zargarian D, Alizadeh AM, Karami K, Saeidifar M, Khalighfard S, Dubrulle L, Zakariazadeh M, Cloutier JP, Sohrabijam Z (2018). In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity. Dalton Transactions, 47(47), 16944-16957.

Chicago

Hosseinikharat M, Zargarian D, Alizadeh AM, Karami K, Saeidifar M, Khalighfard S, Dubrulle L, Zakariazadeh M, Cloutier JP, Sohrabijam Z. "In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity." Dalton Transactions 47, no. 47 (2018): 16944-16957.

Harvard

Hosseinikharat M et al. (2018) 'In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity', Dalton Transactions, 47(47), pp. 16944-16957.

Vancouver

Hosseinikharat M, Zargarian D, Alizadeh AM, Karami K, Saeidifar M, Khalighfard S, et al.. In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity. Dalton Transactions. 2018;47(47):16944-16957.

BibTex

@article{ author = {Hosseinikharat M and Zargarian D and Alizadeh AM and Karami K and Saeidifar M and Khalighfard S and Dubrulle L and Zakariazadeh M and Cloutier JP and Sohrabijam Z}, title = {In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity}, journal = {Dalton Transactions}, volume = {47}, number = {47}, pages = {16944-16957}, year = {2018} }

RIS

TY - JOUR
AU - Hosseinikharat M
AU - Zargarian D
AU - Alizadeh AM
AU - Karami K
AU - Saeidifar M
AU - Khalighfard S
AU - Dubrulle L
AU - Zakariazadeh M
AU - Cloutier JP
AU - Sohrabijam Z
TI - In Vitro and in Vivo Antiproliferative Activity of Organo-Nickel Scs-Pincer Complexes on Estrogen Responsive Mcf7 and Mc4l2 Breast Cancer Cells. Effects of Amine Fragment Substitutions on Bsa Binding and Cytotoxicity
JO - Dalton Transactions
VL - 47
IS - 47
SP - 16944
EP - 16957
PY - 2018
ER -

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