Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin

Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin Publisher Pubmed

Cheshmehnoor P¹ ; Rabbani S² ; Haeri A^{1, 3}

Show Affiliations

1. Department of Pharmaceutics & Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2023

Abstract

Aim: To develop quercetin nanocrystals by a simple approach and to evaluate their in vivo antifibrotic efficacy. Materials & methods: Nanosuspensions were fabricated by a thin-film hydration technique and ultrasonication. The influence of process variables on the average diameter of quercetin nanoparticles was investigated. Moreover, in vivo efficacy was investigated in an established murine CCl4-induced fibrosis model. Results: Nanocrystals showed a particle size of <400 nm. The optimized formulations showed an increase in dissolution rate and solubility. Quercetin nanocrystals markedly prevented fibrotic changes in the liver, as evidenced by mitigated histopathological changes and diminished aminotransferase levels and collagen accumulation. Conclusion: The findings reflect the promising potential of quercetin nanocrystals for liver fibrosis prevention. © 2023 Future Medicine Ltd.

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Style	Citing Format
MLA	Cheshmehnoor P, Rabbani S, Haeri A. "Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin." Nanomedicine, vol. 18, no. 2, 2023, pp. 89-107.
APA	Cheshmehnoor P, Rabbani S, Haeri A (2023). Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin. Nanomedicine, 18(2), 89-107.
Chicago	Cheshmehnoor P, Rabbani S, Haeri A. "Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin." Nanomedicine 18, no. 2 (2023): 89-107.
Harvard	Cheshmehnoor P, Rabbani S, Haeri A (2023) 'Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin', Nanomedicine, 18(2), pp. 89-107.
Vancouver	Cheshmehnoor P, Rabbani S, Haeri A. Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin. Nanomedicine. 2023;18(2):89-107.
BibTex	@article{ author = {Cheshmehnoor P and Rabbani S and Haeri A}, title = {Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin}, journal = {Nanomedicine}, volume = {18}, number = {2}, pages = {89-107}, year = {2023} }
RIS	TY - JOUR AU - Cheshmehnoor P AU - Rabbani S AU - Haeri A TI - Quercetin Nanocrystals Prepared by a Novel Technique Improve the Dissolution Rate and Antifibrotic Activity of Quercetin JO - Nanomedicine VL - 18 IS - 2 SP - 89 EP - 107 PY - 2023 ER -

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