Nanoformulations of Natural Products for Management of Metabolic Syndrome Publisher Pubmed



Taghipour YD^{1, 2, 3} ; Hajialyani M⁴ ; Naseri R⁵ ; Hesari M⁶ ; Mohammadi P⁶ ; Stefanucci A⁷ ; Mollica A⁷ ; Farzaei MH^{4, 6} ; Abdollahi M⁸ Show Affiliations
Source: International Journal of Nanomedicine Published:2019

Abstract

Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully. © 2019 Taghipour et al.